医学综述
醫學綜述
의학종술
MEDICAL RECAPITULATE
2014年
24期
4582-4583
,共2页
鼻息肉%嗜酸性粒细胞%趋化因子%基质金属蛋白酶9
鼻息肉%嗜痠性粒細胞%趨化因子%基質金屬蛋白酶9
비식육%기산성립세포%추화인자%기질금속단백매9
Polyps%Eosinophils%Chemokines%Matrix metalloproteinase-9
目的：探讨嗜酸性粒细胞趋化因子(Eotaxin)和基质金属蛋白酶9(MMP-9)在息肉组织中的表达及其与嗜酸性粒细胞( Eos)活化和发病的关系。方法选择2010年7月至2013年7月在荆州市中心医院住院接受鼻息肉手术治疗的患者50例作为观察组,并选取35例鼻外伤及慢性鼻炎患者作为对照组。分别于鼻内镜下摘取观察组患者鼻内息肉组织和对照组患者鼻下甲鼻黏膜组织进行苏木精-伊红染色和免疫组织化学SP染色,观察Eotaxin和MMP-9的表达及Eos浸润情况。结果观察组患者中血清嗜酸粒细胞阳离子蛋白(ECP)水平显著高于对照组[(17.32±4.62)μg/L vs (3.28±1.22)μg/L],差异有统计学意义(P<0.01)。观察组患者Eotaxin阳性细胞数显著高于对照组[(47.25±13.18)个 vs (12.48±10.12)个],差异有统计学意义(P<0.01)。 MMP-9在非鼻息肉的正常损伤鼻内组织中呈弱阳性表达,而在观察组患者中MMP-9均呈强阳性表达,两组平均灰度值比较差异有统计学意义(P<0.01)。结论息肉组织中,Eotaxin和MMP-9可通过增加Eos浸润,引发组织的异常重塑,在鼻息肉存在和发展中起重要作用。
目的：探討嗜痠性粒細胞趨化因子(Eotaxin)和基質金屬蛋白酶9(MMP-9)在息肉組織中的錶達及其與嗜痠性粒細胞( Eos)活化和髮病的關繫。方法選擇2010年7月至2013年7月在荊州市中心醫院住院接受鼻息肉手術治療的患者50例作為觀察組,併選取35例鼻外傷及慢性鼻炎患者作為對照組。分彆于鼻內鏡下摘取觀察組患者鼻內息肉組織和對照組患者鼻下甲鼻黏膜組織進行囌木精-伊紅染色和免疫組織化學SP染色,觀察Eotaxin和MMP-9的錶達及Eos浸潤情況。結果觀察組患者中血清嗜痠粒細胞暘離子蛋白(ECP)水平顯著高于對照組[(17.32±4.62)μg/L vs (3.28±1.22)μg/L],差異有統計學意義(P<0.01)。觀察組患者Eotaxin暘性細胞數顯著高于對照組[(47.25±13.18)箇 vs (12.48±10.12)箇],差異有統計學意義(P<0.01)。 MMP-9在非鼻息肉的正常損傷鼻內組織中呈弱暘性錶達,而在觀察組患者中MMP-9均呈彊暘性錶達,兩組平均灰度值比較差異有統計學意義(P<0.01)。結論息肉組織中,Eotaxin和MMP-9可通過增加Eos浸潤,引髮組織的異常重塑,在鼻息肉存在和髮展中起重要作用。
목적：탐토기산성립세포추화인자(Eotaxin)화기질금속단백매9(MMP-9)재식육조직중적표체급기여기산성립세포( Eos)활화화발병적관계。방법선택2010년7월지2013년7월재형주시중심의원주원접수비식육수술치료적환자50례작위관찰조,병선취35례비외상급만성비염환자작위대조조。분별우비내경하적취관찰조환자비내식육조직화대조조환자비하갑비점막조직진행소목정-이홍염색화면역조직화학SP염색,관찰Eotaxin화MMP-9적표체급Eos침윤정황。결과관찰조환자중혈청기산립세포양리자단백(ECP)수평현저고우대조조[(17.32±4.62)μg/L vs (3.28±1.22)μg/L],차이유통계학의의(P<0.01)。관찰조환자Eotaxin양성세포수현저고우대조조[(47.25±13.18)개 vs (12.48±10.12)개],차이유통계학의의(P<0.01)。 MMP-9재비비식육적정상손상비내조직중정약양성표체,이재관찰조환자중MMP-9균정강양성표체,량조평균회도치비교차이유통계학의의(P<0.01)。결론식육조직중,Eotaxin화MMP-9가통과증가Eos침윤,인발조직적이상중소,재비식육존재화발전중기중요작용。
Objective To investigate the eosinophil chemotactic factor and matrix metalloproteinase-9 (MMP-9) expression in polyps with eosinophils extremely ( Eos) activation and morbidity relationship. Methods 50 cases with nasal polyps admitted to Jingzhou Central Hospital from July 2010 to July 2013 were chosen as observation group,35 cases patients with nasal trauma,chronic rhinitis causes nasal were cho-sen as control group. Endoscopic removal of the study were patients with nasal polyps group and a control group of patients under the nose A nasal tissue HE staining and immunohistochemical SP staining eosinophil chemotactic factor( eotaxin) and MMP-9 expression and eosinophil infiltration. Results The patients serum EPC level in the observation group was significantly higher than the control(17. 32 ± 4. 62) μg/L vs (3. 28 ±1.22) μg/L)(P<0.01). Eotaxin-positive cell counts in observation group was higher than the control [(47.25±13.18)个 vs(12.48±10.12)个](P<0.01).MMP-9inanon-normaldamagenasalpolyp tissue was weakly positive expression,whereas patients in the observation group,MMP-9 showed a strong ex-pression of the average gray value of the two groups reached statistically significant difference compared levels (P<0. 01). Conclusion Eosinophil chemotactic factor and matrix metalloproteinase-9 can increase eosin-ophil infiltration,causing the abnormal tissue remodeling,the existence and development of nasal polyps play an important role.
