CAJ | 학술논문

目的：探讨血浆中肌钙蛋白I( cTnI)、肌钙蛋白T( cTnT)、N端前B型脑钠肽( NT-proBNP)的联合检测在急性心肌梗死( AMI)诊断中的应用价值。方法收集2012年5月至2013年5月宝鸡市第二人民医院收治的以急性胸闷胸痛为主要症状就诊的34例患者为研究对象,以2010年AMI临床诊断与治疗指南( WHO)为金标准将这34例患者分为AMI组20例和非AMI组14例,所有患者在就诊时即抽取血样,用电化学发光法测定两组患者血浆中的cTnI、cTnT、NT-proBNP水平,并分析cT-nI、cTnT和NT-proBNP单独及联合检测诊断AMI的价值。结果 AMI组血浆cTnI、cTnT、NT-proBNP水平均高于非AMI组,差异有统计学意义(P<0.01)。三者联合检测的灵敏度高于NT-proBNP单独检测(χ2=6.23,P<0.05),特异度高于cTnT单独检测(χ2=9.38,P<0.05)。结论 NT-proBNP、cTnI、cTnT联合检测可以提高AMI检测的敏感性,有助于AMI的早期诊断。
목적：탐토혈장중기개단백I( cTnI)、기개단백T( cTnT)、N단전B형뇌납태( NT-proBNP)적연합검측재급성심기경사( AMI)진단중적응용개치。방법수집2012년5월지2013년5월보계시제이인민의원수치적이급성흉민흉통위주요증상취진적34례환자위연구대상,이2010년AMI림상진단여치료지남( WHO)위금표준장저34례환자분위AMI조20례화비AMI조14례,소유환자재취진시즉추취혈양,용전화학발광법측정량조환자혈장중적cTnI、cTnT、NT-proBNP수평,병분석cT-nI、cTnT화NT-proBNP단독급연합검측진단AMI적개치。결과 AMI조혈장cTnI、cTnT、NT-proBNP수평균고우비AMI조,차이유통계학의의(P<0.01)。삼자연합검측적령민도고우NT-proBNP단독검측(χ2=6.23,P<0.05),특이도고우cTnT단독검측(χ2=9.38,P<0.05)。결론 NT-proBNP、cTnI、cTnT연합검측가이제고AMI검측적민감성,유조우AMI적조기진단。
Objective To investigate the value combined detection of plasma cardiac troponin I,cardiac troponin T and NT-proBNP in acute myocardial infarction diagnose. Methods Collected 34 patients who have the with acute chest pain as the main symptom treatment from the department of emergency and cardiol-ogy clinic of Baoji Second People's Hospital since May 2012 to May 2013 for the study,the blood samples were drawn when the patients in the treatment,all the samples use electricity chemiluminescence method to detect the plasma cTnI, cTnT, NT-proBNP concentrations. Results Plasma cTnI, cTnT, AMI NT-proBNP levels were higher than those in non AMI group,the difference was statistically significant(P<0. 01). The sensitivity of combined detection of three higher than those of the NT-proBNP test alone(χ2 =6. 23,P<0. 05),the specificity was higher than that of the cTnT test alone(χ2 =9. 38,P<0. 05). Conclusion NT-proBNP,cTnI,cTnT combined detection of AMI detection sensitivity can be improved to help early diagnosis of AMI.