CAJ | 학술논문

目的：研究妊娠期糖尿病( GDM)患者脂质代谢水平及对新生儿出生体质量和肾功能的影响,为促进产妇健康、提高新生儿质量提供参考。方法收集2013年2月至2014年4月湖北医药学院附属东风医院收治的GDM孕妇39例,正常妊娠期孕妇47例,测定两组孕妇血脂(总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇)水平和两组新生儿血清胱抑素C、β2微球蛋白浓度,并记录两组新生儿出生体质量等。结果 GDM组孕妇血清三酰甘油、总胆固醇水平显著高于正常妊娠组[(3.1±1.4) mmol/L vs (2.0±0.9) mmol/L、(5.9±2.1) mmol/L vs (4.6±1.7) mmol/L,P<0.05],且新生儿体质量及血清胱抑素C、β2微球蛋白较正常妊娠组显著升高(P<0.05)。 GDM组巨大儿出生率升高,新生儿发生早期肾功能损害。 Pearson相关性分析结果显示三酰甘油、总胆固醇水平与新生儿出生体质量、血清胱抑素C、β2微球蛋白的水平呈正相关性(P<0.05)。结论与正常妊娠妇女比较,GDM患者脂质代谢紊乱严重,并对新生儿出生体质量和肾脏功能产生影响。应对妊娠期孕妇进行饮食指导和血脂监测有重要意义。
목적：연구임신기당뇨병( GDM)환자지질대사수평급대신생인출생체질량화신공능적영향,위촉진산부건강、제고신생인질량제공삼고。방법수집2013년2월지2014년4월호북의약학원부속동풍의원수치적GDM잉부39례,정상임신기잉부47례,측정량조잉부혈지(총담고순、삼선감유、고밀도지단백담고순、저밀도지단백담고순)수평화량조신생인혈청광억소C、β2미구단백농도,병기록량조신생인출생체질량등。결과 GDM조잉부혈청삼선감유、총담고순수평현저고우정상임신조[(3.1±1.4) mmol/L vs (2.0±0.9) mmol/L、(5.9±2.1) mmol/L vs (4.6±1.7) mmol/L,P<0.05],차신생인체질량급혈청광억소C、β2미구단백교정상임신조현저승고(P<0.05)。 GDM조거대인출생솔승고,신생인발생조기신공능손해。 Pearson상관성분석결과현시삼선감유、총담고순수평여신생인출생체질량、혈청광억소C、β2미구단백적수평정정상관성(P<0.05)。결론여정상임신부녀비교,GDM환자지질대사문란엄중,병대신생인출생체질량화신장공능산생영향。응대임신기잉부진행음식지도화혈지감측유중요의의。
Objective To study the effects of lipid metabolism in patients with gestational diabetes mellitus ( GDM) on weight and renal function of newborn, and improve the quality of the newborn. Meth-ods 47 normal pregnant women and 39 women with GDM from Dongfeng Hospital Affiliated to Hubei Medical College, 2013. 2~2014. 4, were included in this study. Blood lipid levels ( TC、TG、HDL-c、LDL-c) and serum Cys-C,β2-MG concentration of newborn were measured. And birth weight of two groups of pregnant women were recorded. Results The level of serum TC,TG in GDM group were obvi-ously higher than that of normal pregnancy group[(3.1 ±1.4) mmol/L vs (2.0 ±0.9) mmol/L,(5.9 ±2.1) mmol/L vs (4.6 ±1.7) mmol/L,P<0.05],the weight and Cys-C、β2-MG of newborn in GDM group increased significantly (P<0. 01), sugesting macrosomia birth rate of GDM group increased,early renal damage of the newborn appeared. Pearson correlation analysis showed that TG, TC levels had posi-tive correlation with birth weight, serum Cys-C,levels of β2-MG (P<0. 05). Conclusion Compared with normal pregnant women,lipid metabolic disorder of patients with gestational diabetes is more serious, and make impact on weight and renal function of newborn. To give the dietary guidance to pregnant women and monitor blood lipid during pregnancy has important significance.