医学综述
醫學綜述
의학종술
MEDICAL RECAPITULATE
2014年
24期
4560-4562
,共3页
依折麦布%糖尿病%颈动脉粥样硬化斑块%临床研究
依摺麥佈%糖尿病%頸動脈粥樣硬化斑塊%臨床研究
의절맥포%당뇨병%경동맥죽양경화반괴%림상연구
Ezetimibe%Diabetes%Carotid atherosclerotic plaque%Clinical study
目的：探讨依折麦布治疗糖尿病患者颈动脉粥样硬化斑块的效果。方法选择河北省老年病医院内科2012年5月至2013年5月收治的80例糖尿病颈动脉粥样硬化斑块患者作研究对象,采用随机数字表法分为两组：对照组(40例)单用阿托伐他汀,每次20 mg,每日1次,晚上服用；观察组在对照组基础上联用依折麦布,每次10 mg,每日1次,晚上服用。两组均服用12个月。治疗前及治疗后对两组患者颈动脉内膜中层厚度、超敏C反应蛋白、斑块Crouse积分、血脂水平、颈动脉内径进行测定并比较。结果治疗后,观察组高敏C反应蛋白、低密度脂蛋白胆固醇相较疗前降低[(4.38±1.24)mg/Lvs(7.07±2.59)mg/L；(2.12±0.46)mmol/Lvs(3.18±0.45)mmol/L,P<0.05],治疗后观察组颈动脉内膜中层厚度、斑块Crouse积分对比治疗前好转[(1.02±0.11) mm vs (1.27±0.22) mm；(3.81±1.23)分vs(4.29±1.62)分P<0.05]。治疗后观察组颈动脉内膜中层厚度、斑块Crouse积分改善优于对照组(P<0.05)。结论糖尿病患者颈动脉粥样硬化斑块在他汀类药物的基础上应用依折麦布治疗,可显著改善临床症状,提高临床治疗效果,保障患者生存质量。
目的：探討依摺麥佈治療糖尿病患者頸動脈粥樣硬化斑塊的效果。方法選擇河北省老年病醫院內科2012年5月至2013年5月收治的80例糖尿病頸動脈粥樣硬化斑塊患者作研究對象,採用隨機數字錶法分為兩組：對照組(40例)單用阿託伐他汀,每次20 mg,每日1次,晚上服用；觀察組在對照組基礎上聯用依摺麥佈,每次10 mg,每日1次,晚上服用。兩組均服用12箇月。治療前及治療後對兩組患者頸動脈內膜中層厚度、超敏C反應蛋白、斑塊Crouse積分、血脂水平、頸動脈內徑進行測定併比較。結果治療後,觀察組高敏C反應蛋白、低密度脂蛋白膽固醇相較療前降低[(4.38±1.24)mg/Lvs(7.07±2.59)mg/L；(2.12±0.46)mmol/Lvs(3.18±0.45)mmol/L,P<0.05],治療後觀察組頸動脈內膜中層厚度、斑塊Crouse積分對比治療前好轉[(1.02±0.11) mm vs (1.27±0.22) mm；(3.81±1.23)分vs(4.29±1.62)分P<0.05]。治療後觀察組頸動脈內膜中層厚度、斑塊Crouse積分改善優于對照組(P<0.05)。結論糖尿病患者頸動脈粥樣硬化斑塊在他汀類藥物的基礎上應用依摺麥佈治療,可顯著改善臨床癥狀,提高臨床治療效果,保障患者生存質量。
목적：탐토의절맥포치료당뇨병환자경동맥죽양경화반괴적효과。방법선택하북성노년병의원내과2012년5월지2013년5월수치적80례당뇨병경동맥죽양경화반괴환자작연구대상,채용수궤수자표법분위량조：대조조(40례)단용아탁벌타정,매차20 mg,매일1차,만상복용；관찰조재대조조기출상련용의절맥포,매차10 mg,매일1차,만상복용。량조균복용12개월。치료전급치료후대량조환자경동맥내막중층후도、초민C반응단백、반괴Crouse적분、혈지수평、경동맥내경진행측정병비교。결과치료후,관찰조고민C반응단백、저밀도지단백담고순상교료전강저[(4.38±1.24)mg/Lvs(7.07±2.59)mg/L；(2.12±0.46)mmol/Lvs(3.18±0.45)mmol/L,P<0.05],치료후관찰조경동맥내막중층후도、반괴Crouse적분대비치료전호전[(1.02±0.11) mm vs (1.27±0.22) mm；(3.81±1.23)분vs(4.29±1.62)분P<0.05]。치료후관찰조경동맥내막중층후도、반괴Crouse적분개선우우대조조(P<0.05)。결론당뇨병환자경동맥죽양경화반괴재타정류약물적기출상응용의절맥포치료,가현저개선림상증상,제고림상치료효과,보장환자생존질량。
Objective To investigate the carotid atherosclerosis plaque in patients with diabetes by treatment with ezetimibe. Methods 80 cases of diabetic patients with carotid atherosclerotic plaque as study objects,are hospital senile disease in Hebei province in 2012 May to 2013 May in our hospital department of internal medicine, were randomly divided into observation group and control group, each 40 cases, control group with atorvastatin 20 mg/time,1 times/day,night use,take 12 months. In the treatment group combined with ezetimibe 10 mg/time,1 times/day,night use,take 12 months. Before treatment and after treatment on carotid artery intima media thickness,high sensitive C reactive protein,plaque Crouse integral,blood lipid level,diameter of carotid artery were detected before and after the treatment were compared in. Results The observation group of high sensitive C reactive protein,low density lipoprotein cholesterol compared with before treatment results after treatment[(4.38 ±1.24) mg/L vs (7.07 ±2.59) mg/L,(2.12 ±0.46) mmol/L vs (3.18±0.45) mmol/L,P<0.05],after the treatment,the observation group carotid intima-media thick-ness,plaque Crouse integral contrast before treatment,better performance[(1.02 ±0.11) mm vs (1.27 ±0. 22) mm,(3.81±1.23) vs(4.29±1.62) ,P<0.05].Aftertreatment,theobservationgroupcarotidinti-ma-media thickness,plaque integral Crouse was better than the control group (P<0. 05). Conclusion Ca-rotid atherosclerosis plaques in diabetic patients on statins,with ezetimibe treatment,can significantly improve the clinical symptoms,improve the clinical treatment effect,guarantee the quality of life of patients with.
