医学综述
醫學綜述
의학종술
MEDICAL RECAPITULATE
2014年
24期
4541-4542
,共2页
新生儿败血症%降钙素原%白细胞介素6%序贯器官功能衰竭评估/危重评分
新生兒敗血癥%降鈣素原%白細胞介素6%序貫器官功能衰竭評估/危重評分
신생인패혈증%강개소원%백세포개소6%서관기관공능쇠갈평고/위중평분
Neonatal sepsis%Rocalcitonin%Interleukin-6%Sequential organ failure assessment /pediat-ric critical illness score
目的：研究血清降钙素原( PCT)及白细胞介素6( IL-6)水平在新生儿败血症早期诊断中的临床价值。方法将2011年1月至2012年12月期间在高州市人民卫生院就诊的100例新生儿败血症患者纳入败血症组,同期分娩的100例健康新生儿纳入健康组,采集外周血检测PCT及IL-6水平,并通过序贯器官功能衰竭评估( SOFA)评分、危重评分系统( PCIS)评分判断全身情况。结果与健康组比较,败血症组患儿PCT、IL-6水平及SOFA评分均高于健康组[(13.8±2.5)μg/L vs (2.8±0.1)μg/L,(272.9±43.6) ng/L vs (58.5±8.2) ng/L,(8.8±1.3)分vs (2.3±0.5)分],PCIS评分低于健康组[(72.1±11.4)分 vs(95.8±13.1)分],差异均有统计学意义(P<0.05)；SOFA评分与PCT、IL-6水平呈正相关(P<0.05),PCIS评分与PCT、IL-6水平呈负相关(P<0.05)；PCT、IL-6两项指标联合检查灵敏度为94%、特异度为96%,均高于两项指标单独检测(P<0.05)。结论新生儿败血症患者的PCT及IL-6水平明显升高,且与疾病的严重程度密切相关,两项指标联合检测可提高敏感性和特异性。
目的：研究血清降鈣素原( PCT)及白細胞介素6( IL-6)水平在新生兒敗血癥早期診斷中的臨床價值。方法將2011年1月至2012年12月期間在高州市人民衛生院就診的100例新生兒敗血癥患者納入敗血癥組,同期分娩的100例健康新生兒納入健康組,採集外週血檢測PCT及IL-6水平,併通過序貫器官功能衰竭評估( SOFA)評分、危重評分繫統( PCIS)評分判斷全身情況。結果與健康組比較,敗血癥組患兒PCT、IL-6水平及SOFA評分均高于健康組[(13.8±2.5)μg/L vs (2.8±0.1)μg/L,(272.9±43.6) ng/L vs (58.5±8.2) ng/L,(8.8±1.3)分vs (2.3±0.5)分],PCIS評分低于健康組[(72.1±11.4)分 vs(95.8±13.1)分],差異均有統計學意義(P<0.05)；SOFA評分與PCT、IL-6水平呈正相關(P<0.05),PCIS評分與PCT、IL-6水平呈負相關(P<0.05)；PCT、IL-6兩項指標聯閤檢查靈敏度為94%、特異度為96%,均高于兩項指標單獨檢測(P<0.05)。結論新生兒敗血癥患者的PCT及IL-6水平明顯升高,且與疾病的嚴重程度密切相關,兩項指標聯閤檢測可提高敏感性和特異性。
목적：연구혈청강개소원( PCT)급백세포개소6( IL-6)수평재신생인패혈증조기진단중적림상개치。방법장2011년1월지2012년12월기간재고주시인민위생원취진적100례신생인패혈증환자납입패혈증조,동기분면적100례건강신생인납입건강조,채집외주혈검측PCT급IL-6수평,병통과서관기관공능쇠갈평고( SOFA)평분、위중평분계통( PCIS)평분판단전신정황。결과여건강조비교,패혈증조환인PCT、IL-6수평급SOFA평분균고우건강조[(13.8±2.5)μg/L vs (2.8±0.1)μg/L,(272.9±43.6) ng/L vs (58.5±8.2) ng/L,(8.8±1.3)분vs (2.3±0.5)분],PCIS평분저우건강조[(72.1±11.4)분 vs(95.8±13.1)분],차이균유통계학의의(P<0.05)；SOFA평분여PCT、IL-6수평정정상관(P<0.05),PCIS평분여PCT、IL-6수평정부상관(P<0.05)；PCT、IL-6량항지표연합검사령민도위94%、특이도위96%,균고우량항지표단독검측(P<0.05)。결론신생인패혈증환자적PCT급IL-6수평명현승고,차여질병적엄중정도밀절상관,량항지표연합검측가제고민감성화특이성。
Objective To study the clinical l value of serum procalcitonin and interleukin-6 level in ear-ly diagnosis of neonatal sepsis. Methods 100 cases of neonatal sepsis patients were enrolled in septicemia group and 100 cases of newborn infants during the same period were enrolled healthy group. Then serum pro-calcitonin and interleukin-6 level were detected, general condition were judged by SOFA score and PCIS score. Results PCT、IL-6 level and SOFA score(8.8 ±1.3)of septicemia group were higher than healthy group [(13.8 ±2.5) μg/L vs (2.8 ±0.1) μg/L,(272.9 ±43.6) ng/L vs (58.5 ±8.2) ng/L,(8.8 ± 1.3) scorevs(2.3±0.5) score]( (P<0.05).PCISscorewaslowerthanhealthygroup[(72.1±11.4) scorevs(095.8±13.1)score]((P<0.05).SOFAscorewerepositivelycorrelatedwithPCT,IL-6level, PCIS score was negatively correlated with PCT,IL-6 level(P<0. 05);Sensitivity and specificity of PCT,IL-6 joint detection were separately 94% and 96%,which were higher than single detection(P<0. 05). Con-clusion PCT,IL-6 levels are increased in neonatal sepsis and closely related to the severity of disease,com-bined detection of two indexes can improve the sensitivity and specificity.
