CAJ | 학술논문

肿瘤干细胞学说对肿瘤起源的传统理论提出了质疑，并已获得较多的证据支持，正逐渐被人们所接受。肿瘤干细胞学说为恶性肿瘤的基础研究及临床治疗指明了一个新的方向。原发性肝癌在我国的发病率较高，且呈上升趋势。近年来研究发现，肝癌细胞中存在着一群具有特异性的肿瘤细胞，称为肝癌干细胞，其发现促使人们对原有的关于肝癌形成、发展及治疗理论进行重新审视。该文试从干细胞的概念、肿瘤干细胞学说的形成及其生物学特性、肝癌干细胞的来源及表面标志物的研究进展等方面作一综述。
종류간세포학설대종류기원적전통이론제출료질의，병이획득교다적증거지지，정축점피인문소접수。종류간세포학설위악성종류적기출연구급림상치료지명료일개신적방향。원발성간암재아국적발병솔교고，차정상승추세。근년래연구발현，간암세포중존재착일군구유특이성적종류세포，칭위간암간세포，기발현촉사인문대원유적관우간암형성、발전급치료이론진행중신심시。해문시종간세포적개념、종류간세포학설적형성급기생물학특성、간암간세포적래원급표면표지물적연구진전등방면작일종술。
Tumor stem cell theory has challenged the traditional theory of tumor origin and has got quite a few evidences,the new theory has been accepted gradually by people. Tumor stem cell theory has showed a new direction for both basic research and clinical treatment of malignat tumors. In China,the incidence of pri-mary liver cancer is relatively higher,and shows an increasing trend. Recent research shows that there is a special group of tumor cells in the liver cancer cells,which are called? liver cancer stem cells. This new find-ing has changed people's traditional ideas about the etiology,development and treatment of liver cancer. This article will summarizes the concept of stem cells,? the formation of tumor stem cell theory, the biological characteristics of tumor stem cells,the origin of liver cancer stem cells and tumor surface markers.