CAJ | 학술논문

胶质瘤是常见的中枢神经系统肿瘤，组蛋白去乙酰化酶( HDACs)是最新发现的一系列致癌因子，在很多实体肿瘤中发挥重要作用，在脑胶质瘤中也不例外。其中的组蛋白去乙酰化酶3( HDAC3)是最近研究的热点，国内外很多学者发现其在人类肿瘤中起到了致癌的作用。人们应用抑制剂减弱HDAC3的表达后，人脑胶质瘤细胞的生长、侵袭等能力出现明显减弱。这就为肿瘤治疗提供了一条新途径。
효질류시상견적중추신경계통종류，조단백거을선화매( HDACs)시최신발현적일계렬치암인자，재흔다실체종류중발휘중요작용，재뇌효질류중야불예외。기중적조단백거을선화매3( HDAC3)시최근연구적열점，국내외흔다학자발현기재인류종류중기도료치암적작용。인문응용억제제감약HDAC3적표체후，인뇌효질류세포적생장、침습등능력출현명현감약。저취위종류치료제공료일조신도경。
Glioma is a common central nervous system tumors,histone deacetylases( HDACs) are a se-ries of newly discovered cancer-causing factors play an important role in many solid tumors,in gliomas is no exception. Which histone deacetylase 3(HDAC3) is a recent research focus,many scholars found it played a role in carcinogenesis in human tumors. After people apply HDAC3 inhibitors reduced the expression of hu-man glioma cell growth,invasion,such as the ability to appear significantly reduced. This provides a new way for cancer treatment.