CAJ | 학술논문

非酒精性脂肪性肝病( NAFLD)是代谢综合征在肝脏的组成部分,是全球范围内广泛流行的慢性肝病。胰岛素抵抗( IR)可引起肝脏糖脂代谢紊乱,导致脂肪变。脂肪因子和炎性因子相互作用可导致IR,引起脂肪肝炎性改变,使NAFLD患者进展为非酒精性脂肪性肝炎( NASH)、肝纤维化甚至肝细胞癌。鉴于此,胰岛素增敏剂二甲双胍及噻唑烷二酮类药物能有效地治疗NAFLD。该文就NAFLD的发病机制与胰岛素增敏剂抗病机制及疗效予以综述。
비주정성지방성간병( NAFLD)시대사종합정재간장적조성부분,시전구범위내엄범류행적만성간병。이도소저항( IR)가인기간장당지대사문란,도치지방변。지방인자화염성인자상호작용가도치IR,인기지방간염성개변,사NAFLD환자진전위비주정성지방성간염( NASH)、간섬유화심지간세포암。감우차,이도소증민제이갑쌍고급새서완이동류약물능유효지치료NAFLD。해문취NAFLD적발병궤제여이도소증민제항병궤제급료효여이종술。
Nonalcoholic fatty liver disease(NAFLD),which is a part of the metabolic syndrome in the liver part,is a worldwide chronic liver disease. Insulin resistance( IR) causes liver lipid metabolism disturb-ance,leading to hepatic steatosis. The interaction between adipokines and cytokines leads to insulin resistance ( IR) ,and also can change fat hepatitis at the same time,resulting in NAFLD patients progressing to nonalco-holic steatohepatitis( NASH) ,liver fibrosis or hepatocellular carcinoma. Insulin resistance plays an important role in the pathogenesis of NAFLD. Insulin sensitizers ( metformin and thiazolidinedione ) can improve insu-lin resistance and regulate adipokines and cytokines in patients of NAFLD. In this paper the pathogenesis of NAFLD and insulin sensitizers′resistant mechanism and efficacy in NAFLD are reviewed.