医学综述
醫學綜述
의학종술
MEDICAL RECAPITULATE
2014年
24期
4428-4430
,共3页
甘玉英(综述)%崔学范(审校)
甘玉英(綜述)%崔學範(審校)
감옥영(종술)%최학범(심교)
人β防御素2%呼吸系统疾病%临床评价
人β防禦素2%呼吸繫統疾病%臨床評價
인β방어소2%호흡계통질병%림상평개
Human beita defensin 2%Pulmonary disease%Clinical evaluation
人β防御素2(HBD2)是一类在肺部上皮呈可诱导性表达的抗菌肽。由于其抗菌活性和免疫调节功能,HBD2在肺部感染和炎症性疾病中发挥重要作用,可能参与肺部疾病的发生、发展。故检测肺组织或体液中HBD2的水平对临床上指导肺部疾病的诊疗有积极的作用。该文就HBD2的结构、功能及其作为一个炎性因子在评价肺部疾病中临床应用进展予以综述。
人β防禦素2(HBD2)是一類在肺部上皮呈可誘導性錶達的抗菌肽。由于其抗菌活性和免疫調節功能,HBD2在肺部感染和炎癥性疾病中髮揮重要作用,可能參與肺部疾病的髮生、髮展。故檢測肺組織或體液中HBD2的水平對臨床上指導肺部疾病的診療有積極的作用。該文就HBD2的結構、功能及其作為一箇炎性因子在評價肺部疾病中臨床應用進展予以綜述。
인β방어소2(HBD2)시일류재폐부상피정가유도성표체적항균태。유우기항균활성화면역조절공능,HBD2재폐부감염화염증성질병중발휘중요작용,가능삼여폐부질병적발생、발전。고검측폐조직혹체액중HBD2적수평대림상상지도폐부질병적진료유적겁적작용。해문취HBD2적결구、공능급기작위일개염성인자재평개폐부질병중림상응용진전여이종술。
Human β defensin 2 is an inducible antimicrobial? peptide mainly expressed in lung epithe-lium. Based on their antimicrobial and immunomodulatoy functions,HBD2 are probably involved in the patho-genesis of infectious and inflammatory diseases of the lung. So measuring HBD2 level of lung tissue or bodily fluids have a positive effect for diagnosis and treatment of lung disease. This article summarizes current knowledge of HBD2 about its structure,biological function and clinical research progress in pulmonary disea-ses.
