CAJ | 학술논문

α突触核蛋白(α-Syn)是一种小分子酸性可溶性蛋白，是帕金森病发病的病理基础，在帕金森病的发生中起着重要作用。该文对α-Syn的结构、功能及其导致帕金森病的发病机制等方面进行了综述，结合近年来对遗传性脊髓小脑型共济失调2型(SCA2)与α-Syn关系的研究来阐述带有帕金森症状的SCA2的发病是否与帕金森病的发病有共同的发病基础，是否也是α-Syn异常聚集所致，尚待进一步考证。
α돌촉핵단백(α-Syn)시일충소분자산성가용성단백，시파금삼병발병적병리기출，재파금삼병적발생중기착중요작용。해문대α-Syn적결구、공능급기도치파금삼병적발병궤제등방면진행료종술，결합근년래대유전성척수소뇌형공제실조2형(SCA2)여α-Syn관계적연구래천술대유파금삼증상적SCA2적발병시부여파금삼병적발병유공동적발병기출，시부야시α-Syn이상취집소치，상대진일보고증。
α-synuclein is a small molecule of acid soluble proteins,the incidence of the pathological ba-sis of Parkinson′s disease,plays an important role in the genesis of Parkinson′s disease. Aspects of this pa-per,the α-synuclein structure, function and lead to the pathogenesis of Parkinson′s disease were reviewed, combined with recent hereditary spinocerebellar ataxia (SCA2) 2 andα-synaptic nuclear protein-to illustrate whether hereditary spinocerebellar ataxia (SCA2) 2 with the onset of Parkinson′s symptoms have a common basis of the incidence and onset of Parkinson′s disease, whether it is abnormal aggregation of α-synuclein due,pending further research.