医学理论与实践
醫學理論與實踐
의학이론여실천
The Journal of Medical Theory and Practice
2014年
24期
3259-3260,3266
,共3页
急性冠脉综合征%C-反应蛋白%白细胞介素-6%预测价值
急性冠脈綜閤徵%C-反應蛋白%白細胞介素-6%預測價值
급성관맥종합정%C-반응단백%백세포개소-6%예측개치
Acute coronary syndrome%C-reactive protein%Interleukin-6%Predictive value
目的：探讨 C‐反应蛋白（C‐reactive protein ，CRP）、白细胞介素‐6（Interleukin‐6，IL‐6）等炎症标志物在急性冠脉综合征（Acute coronary syndrome ，ACS）及心脏事件发生中的预测价值。方法：监测92名 ACS 患者在住院及随访过程中血 CRP 、IL‐6浓度变化并探讨其 ACS 、心脏不良事件发生之间的内在联系。结果：ACS 患者 CRP 、IL‐6浓度较对照组明显增高，二者相关性良好（r ＝0．67，P＜0．01），经治疗后显著下降（P＜0．01）；住院及随访期间，发生心脏事件患者 CRP 、IL‐6浓度显著高于未发生组，差异均有统计学意义（P＜0．01）；CRP 在住院和随访期间对心脏不良事件预测的敏感度／特异性为：90．7％／79．6％、88．9％／80．9％；IL‐6在住院和随访期间对心脏不良事件预测的敏感度／特异性为：85．9％／82．7％、84．2％／85．0％。结论：炎症反应与 ACS 的发生、发展有关，监测血中 CRP 、IL‐6等炎症标志物的水平对 ACS 诊断、预后评估及中、近期心脏事件发生有较高的预测价值。
目的：探討 C‐反應蛋白（C‐reactive protein ，CRP）、白細胞介素‐6（Interleukin‐6，IL‐6）等炎癥標誌物在急性冠脈綜閤徵（Acute coronary syndrome ，ACS）及心髒事件髮生中的預測價值。方法：鑑測92名 ACS 患者在住院及隨訪過程中血 CRP 、IL‐6濃度變化併探討其 ACS 、心髒不良事件髮生之間的內在聯繫。結果：ACS 患者 CRP 、IL‐6濃度較對照組明顯增高，二者相關性良好（r ＝0．67，P＜0．01），經治療後顯著下降（P＜0．01）；住院及隨訪期間，髮生心髒事件患者 CRP 、IL‐6濃度顯著高于未髮生組，差異均有統計學意義（P＜0．01）；CRP 在住院和隨訪期間對心髒不良事件預測的敏感度／特異性為：90．7％／79．6％、88．9％／80．9％；IL‐6在住院和隨訪期間對心髒不良事件預測的敏感度／特異性為：85．9％／82．7％、84．2％／85．0％。結論：炎癥反應與 ACS 的髮生、髮展有關，鑑測血中 CRP 、IL‐6等炎癥標誌物的水平對 ACS 診斷、預後評估及中、近期心髒事件髮生有較高的預測價值。
목적：탐토 C‐반응단백（C‐reactive protein ，CRP）、백세포개소‐6（Interleukin‐6，IL‐6）등염증표지물재급성관맥종합정（Acute coronary syndrome ，ACS）급심장사건발생중적예측개치。방법：감측92명 ACS 환자재주원급수방과정중혈 CRP 、IL‐6농도변화병탐토기 ACS 、심장불량사건발생지간적내재련계。결과：ACS 환자 CRP 、IL‐6농도교대조조명현증고，이자상관성량호（r ＝0．67，P＜0．01），경치료후현저하강（P＜0．01）；주원급수방기간，발생심장사건환자 CRP 、IL‐6농도현저고우미발생조，차이균유통계학의의（P＜0．01）；CRP 재주원화수방기간대심장불량사건예측적민감도／특이성위：90．7％／79．6％、88．9％／80．9％；IL‐6재주원화수방기간대심장불량사건예측적민감도／특이성위：85．9％／82．7％、84．2％／85．0％。결론：염증반응여 ACS 적발생、발전유관，감측혈중 CRP 、IL‐6등염증표지물적수평대 ACS 진단、예후평고급중、근기심장사건발생유교고적예측개치。
Objective :To investigate the value of serum C‐reactive protein (CRP) and interleukin‐6 (IL‐6) in predic‐ting diseases in patients with acute coronary syndrome (ACS) and cardiac events .Methods :92 patients with ACS were recruited in this study .The concentration changes of serum CRP and IL‐6 were noted .Results :The levels of serum CRP and IL‐6 in patients with ACS were significantly higher than the control group ,with a good correlation (r= 0 .67 ,P<0 .01) ,decreased after treatment (P< 0 .01) .The levels of serum CRP and IL‐6 in patients with cardiac events were significantly higher than that without cardiac events for inpatients and patients followed up for 12 months(P< 0 .01) . The sensitivity and specificity of CRP in predicting adverse cardiac events were 90 .7% and 79 .6% for inpatients ,and 88 .9% and 80 .9% for patients followed up for 12 months .The sensitivity and specificity of IL‐6 were 85 .9% and 82.7% for inpatients ,and 84 .2% and 85 .0% for patients followed up for 12 months .Conclusion :Inflammatory reac‐tion is correlated with ACS .The concentration of serum CRP and IL‐6 are important in the diagnosis ,treatment ,prog‐nosis of cardiac events for the patients ACS .
