CAJ | 학술논문

蒽醌类化合物(anthraquinones)是大黄、何首乌、决明子、芦荟等植物的主要活性成分，药理作用广泛，如泻下、抗菌、保肝利胆等。目前，含有蒽醌的中药或中成药广泛应用于便秘、慢性肾功能衰竭等多种疾病，但是由于服用含蒽醌成分的中药而引起大肠黑病变的报道日益增加，蒽醌类化合物的毒性越来越受到人们的重视。本研究总结了近年来对蒽醌毒理作用的基础及临床研究，对其在消化系统、泌尿系统、生殖系统中的毒性进行综述，为临床合理应用含有蒽醌的中药或中成药制剂提供参考。
은곤류화합물(anthraquinones)시대황、하수오、결명자、호회등식물적주요활성성분，약리작용엄범，여사하、항균、보간리담등。목전，함유은곤적중약혹중성약엄범응용우편비、만성신공능쇠갈등다충질병，단시유우복용함은곤성분적중약이인기대장흑병변적보도일익증가，은곤류화합물적독성월래월수도인문적중시。본연구총결료근년래대은곤독리작용적기출급림상연구，대기재소화계통、비뇨계통、생식계통중적독성진행종술，위림상합리응용함유은곤적중약혹중성약제제제공삼고。
Anthraquinones are the major active components of rhubarb, radix polygoni multiflori, semen cassiae, aloe vera and many other medicinal plants. They are widely used in the pharmaceutical industry due to its diarrhea, an-tibacterial, liver-protective and cholagogue properties. Present uses of Chinese medicine containing anthraquinones are for the treatment of constipation and chronic renal failure. However, there are more increased reports on melanosis coli as a result of using anthraquinones containing drugs, which, leads to increased research in the field. This paper focuses on the toxicological effects in digestive system, urinary system and reproductive system during these years. It is neces-sary and crucial to provide proper reference for safer clinical use of traditional Chinese medicines with anthraquinones components and Chinese medicine preparations.