中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2014年
35期
25-27,35
,共4页
栾慧明%袁国桢%周振和%赵幸福
欒慧明%袁國楨%週振和%趙倖福
란혜명%원국정%주진화%조행복
抑郁症%重复经颅磁刺激%舍曲林%汉密尔顿抑郁量表
抑鬱癥%重複經顱磁刺激%捨麯林%漢密爾頓抑鬱量錶
억욱증%중복경로자자격%사곡림%한밀이돈억욱량표
Depression%Repetitive transcranial magnetic stimulation%Sertraline%HAMD
目的：探讨重复经颅磁刺激(rTMS)对抑郁症患者的辅助治疗作用。方法将2013年10月~2014年3月南京医科大学附属无锡市精神卫生中心收治的符合中国精神障碍分类与诊断标准第3版(CCMD-3)抑郁症诊断标准的44例患者随机分为研究组(n=22)和对照组(n =22)。研究组给予舍曲林联合rTMS治疗，治疗总次数为10次。对照组给予单纯舍曲林治疗。在治疗前(基线)、治疗第2、4周以及8周末应用汉密尔顿抑郁量表(HAMD-24)进行评分；第8周末评定不良反应。结果治疗前两组间HAMD-24评分差异无统计学意义(P>0.05)。研究组治疗第2、4、8周HAMD-24评分[(20.32±2.46)、(14.41±2.04)、(11.36±3.50)分]与对照组[(22.73±2.83)、(16.36±1.79)、(13.41±3.13)分]比较，差异有统计学意义(P <0.01或P <0.05)。治疗第2、4、8周末研究组与对照组HAMD-24评分与治疗前比较均降低(均P<0.01)。研究组显效率为86.4%，总有效率为95.5%。对照组显效率为63.6%，总有效率为90.9%。两组疗效比较差异无统计学意义(χ2=5.50，P>0.05)。第8周末研究组与对照组不良反应发生率比较差异无统计学意义(χ2=2.72，P>0.05)。结论高频rTMS对抑郁症具有辅助治疗作用。
目的：探討重複經顱磁刺激(rTMS)對抑鬱癥患者的輔助治療作用。方法將2013年10月~2014年3月南京醫科大學附屬無錫市精神衛生中心收治的符閤中國精神障礙分類與診斷標準第3版(CCMD-3)抑鬱癥診斷標準的44例患者隨機分為研究組(n=22)和對照組(n =22)。研究組給予捨麯林聯閤rTMS治療，治療總次數為10次。對照組給予單純捨麯林治療。在治療前(基線)、治療第2、4週以及8週末應用漢密爾頓抑鬱量錶(HAMD-24)進行評分；第8週末評定不良反應。結果治療前兩組間HAMD-24評分差異無統計學意義(P>0.05)。研究組治療第2、4、8週HAMD-24評分[(20.32±2.46)、(14.41±2.04)、(11.36±3.50)分]與對照組[(22.73±2.83)、(16.36±1.79)、(13.41±3.13)分]比較，差異有統計學意義(P <0.01或P <0.05)。治療第2、4、8週末研究組與對照組HAMD-24評分與治療前比較均降低(均P<0.01)。研究組顯效率為86.4%，總有效率為95.5%。對照組顯效率為63.6%，總有效率為90.9%。兩組療效比較差異無統計學意義(χ2=5.50，P>0.05)。第8週末研究組與對照組不良反應髮生率比較差異無統計學意義(χ2=2.72，P>0.05)。結論高頻rTMS對抑鬱癥具有輔助治療作用。
목적：탐토중복경로자자격(rTMS)대억욱증환자적보조치료작용。방법장2013년10월~2014년3월남경의과대학부속무석시정신위생중심수치적부합중국정신장애분류여진단표준제3판(CCMD-3)억욱증진단표준적44례환자수궤분위연구조(n=22)화대조조(n =22)。연구조급여사곡림연합rTMS치료，치료총차수위10차。대조조급여단순사곡림치료。재치료전(기선)、치료제2、4주이급8주말응용한밀이돈억욱량표(HAMD-24)진행평분；제8주말평정불량반응。결과치료전량조간HAMD-24평분차이무통계학의의(P>0.05)。연구조치료제2、4、8주HAMD-24평분[(20.32±2.46)、(14.41±2.04)、(11.36±3.50)분]여대조조[(22.73±2.83)、(16.36±1.79)、(13.41±3.13)분]비교，차이유통계학의의(P <0.01혹P <0.05)。치료제2、4、8주말연구조여대조조HAMD-24평분여치료전비교균강저(균P<0.01)。연구조현효솔위86.4%，총유효솔위95.5%。대조조현효솔위63.6%，총유효솔위90.9%。량조료효비교차이무통계학의의(χ2=5.50，P>0.05)。제8주말연구조여대조조불량반응발생솔비교차이무통계학의의(χ2=2.72，P>0.05)。결론고빈rTMS대억욱증구유보조치료작용。
Objective To discuss the auxiliary therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) on patients with depression. Methods 44 patients with CCMD-3 diagnosed depression admitted to Wuxi Mental Health Center Affiliated to Nanjing Medical University from October 2013 to March 2014 were randomly divided into study group (n= 22) and control group (n = 22). A combination of Sertraline and rTMS was adopted for the study group with a total number of 10 time and pure Sertraline treatment was applied to the control group. HAMD-24 was employed to score at baseline (before treatment) and at the end of the 2nd, 4th and 8th week. Adverse reactions were rated after the treatment of 8 weeks. Results The difference in HAMD-24 scores between the two groups was not statistically signifi-cant before treatment (P>0.05). In the study group, the HAMD-24 scores after the treatment of 2, 4, 8 weeks were re-spectively (20.32±2.46), (14.41±2.04) points and (11.36±3.50) points, which were respectively (22.73±2.83), (16.36±1.79) points and (13.41±3.13) points in the control group. Therefore, the differences in HAMD-24 scores between the two groups were statistically significant (P< 0.01 or P<0.05). The HAMD-24 scores at the end of 2nd, 4th and 8th week were lower than those before treatment in study group and control group (all P<0.01). The excellent efficiency in study group was 86.4%, with the total effect rate of 95.5%. The excellent efficiency in control group was 63.6%, with the total effect rate of 90.9%. The efficacy of study group and the control group had no statistical significance (χ2=5.50, P>0.05). There was no statistical significance of the incidence of adverse reactions at the end of 8th week between the study group and the control group (χ2=2.72, P>0.05). Conclusion High frequency rTMS has auxiliary therapy effect on depression.
