CAJ | 학술논문

目的：探讨大剂量辅酶Q10在治疗轻中度血管性认知障碍的疗效评价。方法在2010年10月至2011年6月我院神经科门诊经确诊的轻中度血管性认知障碍的患者86例，随机均分为对照组及观察组。对照组控制各种血管危险因素治疗；观察组在控制各种血管危险因素基础上加用辅酶Q10100mg，每天3次。两组疗程均为2年。结果治疗后观察组MMSE评分明显大于对照组，且差异存在统计学意义（P<0.05）。观察组Barthel指数明显大于对照组，且差异存在统计学意义（P<0.05）。结论辅酶Q10具有抗氧化作用和膜稳定作用，能延缓轻中度血管性认知障碍的发展，且在临床运用中具有良好的安全性和耐受性。
목적：탐토대제량보매Q10재치료경중도혈관성인지장애적료효평개。방법재2010년10월지2011년6월아원신경과문진경학진적경중도혈관성인지장애적환자86례，수궤균분위대조조급관찰조。대조조공제각충혈관위험인소치료；관찰조재공제각충혈관위험인소기출상가용보매Q10100mg，매천3차。량조료정균위2년。결과치료후관찰조MMSE평분명현대우대조조，차차이존재통계학의의（P<0.05）。관찰조Barthel지수명현대우대조조，차차이존재통계학의의（P<0.05）。결론보매Q10구유항양화작용화막은정작용，능연완경중도혈관성인지장애적발전，차재림상운용중구유량호적안전성화내수성。
Objective?Explore?the?large?doses?of?coenzyme?Q10 in the evaluation of the efifcacy of the treatment of mild to moderate vascular cognitive impairment.?Methods?86?patients?with?mild?to?moderate?vascular?cognitive?impairment?in?outpatient?from?in?October?2010?to?June?2011?were?enrolled?in?this?study?and?randomly?divided?into?control?group?and?observation?group.?Two?groups?are?also?to?control?various?vascular?risk?factors,?while?the?observation?group?is?to?use?coenzyme?Q10?100?mg,?three?times?a?day.?The?treatment?lasted?for?2?years.?Results?After?treatment?MMSE?score?and?Barthel?index?of?the?observation group was signiifcantly higher than the control group, and there were statistically signiifcant differences(P<0.05).?Conclusion?Coenzyme?Q10?has?antioxidant?and?membrane?stabilizing?effect,?which?can?delay?the?development?of?mild?to?moderate?vascular?cognitive?impairment?and?has?a?good?safety?and?tolerability?in?clinical?use.