CAJ | 학술논문

目的：探讨难治性与一般性抑郁患者记忆功能及P300指标的差异。方法采用oddball刺激范式,对36例难治抑郁症患者(难治组)、40例非难治性抑郁症患者(非难治组)、38名健康被试(对照组)进行事件相关电位P300测定,测量其P300的潜伏期、波幅。并用韦氏记忆量表评定其记忆功能。结果①与对照组比较,非难治组短时记忆各因子评分(除触摸因子)均显著降低(P<0.05),瞬时记忆、记忆商评分均显著降低(P<0.05)；难治组长时记忆评分(除积累因子)均显著降低(P<0.05),短时记忆评分再认和联想因子均显著下降(P<0.05),瞬时记忆、记忆商评分均显著降低(P<0.05)。②与对照组相比,非难治组P2、N2、P3潜伏期均差异不显著(P>0.05),P3波幅显著降低(P<0.05)；难治组P2、P3潜伏期均显著延迟,P2、N2、P3波幅显著降低(P<0.05)。③与非难治组相比,难治组P2、P3潜伏期均显著延迟,P2、N2、P3波幅显著降低(P<0.05)。结论难治性抑郁症患者瞬时记忆、短时记忆和长时记忆均存在障碍,而一般性抑郁症患者仅瞬时记忆和短时记忆受损。此外,P3受损指标可能是一般性和难治性抑郁患者的共同病理机制标记,而P2、N2受损指标可能是难治性抑郁患者的潜在易感的电生理指标。
목적：탐토난치성여일반성억욱환자기억공능급P300지표적차이。방법채용oddball자격범식,대36례난치억욱증환자(난치조)、40례비난치성억욱증환자(비난치조)、38명건강피시(대조조)진행사건상관전위P300측정,측량기P300적잠복기、파폭。병용위씨기억량표평정기기억공능。결과①여대조조비교,비난치조단시기억각인자평분(제촉모인자)균현저강저(P<0.05),순시기억、기억상평분균현저강저(P<0.05)；난치조장시기억평분(제적루인자)균현저강저(P<0.05),단시기억평분재인화련상인자균현저하강(P<0.05),순시기억、기억상평분균현저강저(P<0.05)。②여대조조상비,비난치조P2、N2、P3잠복기균차이불현저(P>0.05),P3파폭현저강저(P<0.05)；난치조P2、P3잠복기균현저연지,P2、N2、P3파폭현저강저(P<0.05)。③여비난치조상비,난치조P2、P3잠복기균현저연지,P2、N2、P3파폭현저강저(P<0.05)。결론난치성억욱증환자순시기억、단시기억화장시기억균존재장애,이일반성억욱증환자부순시기억화단시기억수손。차외,P3수손지표가능시일반성화난치성억욱환자적공동병리궤제표기,이P2、N2수손지표가능시난치성억욱환자적잠재역감적전생리지표。
Objective To explore the difference of event-related potential(ERP)P300 and memory function between treatment-resistant and non-treatment-resistant depression patients. Methods Using oddball stimulus paradigm,the event-related potentials P300 were test-ed in 36 cases of treatment-resistant depression(TRD group),40 cases of non-treatment-resistant depression(NTRD group),and 38 healthy subjects( control group) ,and P300 amplitudes and latencies were measured. And the memory function was measured by Wechsler memory scale(WMS). Results ①Compared with control group,all factor scores of short-term memory(except the touch factor score) and immediate memory and memory quotient score were significantly decreased in NTRD group(P<0. 05),while all factor scores of long-term memory(except the build-up factor score)were significantly decreased in TRD group(P<0. 05),and the immediate memory and memory quotient score, and recognition and association factors of short-term memory in TRD group were significantly decreased ( P <0. 05).②Compared with control group,no significant difference in latencies of P2,N2,and P3 was found(P>0. 05),and P3 amplitudes were significantly decreased in NTRD group(P<0. 05),while P2 and P3 latencies were significantly enlarged and P2,N2,and P3 ampli-tudes were significantly decreased in TRD group(P<0. 05).③Compared with NTRD group, P2 and P3 latencies were significantly en-larged,and P2,N2,and P3 amplitudes were significantly decreased in TRD group(P<0. 05). Conclusion The treatment-resistant de-pression patients present the impairment of immediate memory,short-term memory and long-term memory,while non-treatment-resistant depression patients only present the impairment of immediate memory and short-term memory. In addition,the damage indicator of P3 may be the marker of common pathological mechanism between treatment-resistant and non-treatment-resistant depression patients,while the impaired indicators of P2 and N2 can be potential susceptible electrophysiological markers for treatment-resistant depression.