CAJ | 학술논문

目的：：探讨左西孟旦对慢性心力衰竭(CHF)急性加重期患者心功能及 N端脑钠肽前体水平的影响.方法：CHF患者55例,随机分为常规治疗组(25例)及左西孟旦(30例,常规治疗基础上加用左西孟旦),比较治疗前后患者心功能变化及 N端脑钠肽前体(NT－pro－BNP)的差异.结果：左西孟旦组的总有效率明显高于常规治疗组(P＜0．05),SV及 LVEF均较常规治疗组显著改善(P＜0．05)；NT－pro－BNP水平与常规治疗组比较有显著下降(P＜0．05).结论：左西孟旦可以明显改善 CHF患者的心功能,降低 NT－pro－BNP水平.
목적：：탐토좌서맹단대만성심력쇠갈(CHF)급성가중기환자심공능급 N단뇌납태전체수평적영향.방법：CHF환자55례,수궤분위상규치료조(25례)급좌서맹단(30례,상규치료기출상가용좌서맹단),비교치료전후환자심공능변화급 N단뇌납태전체(NT－pro－BNP)적차이.결과：좌서맹단조적총유효솔명현고우상규치료조(P＜0．05),SV급 LVEF균교상규치료조현저개선(P＜0．05)；NT－pro－BNP수평여상규치료조비교유현저하강(P＜0．05).결론：좌서맹단가이명현개선 CHF환자적심공능,강저 NT－pro－BNP수평.
Objective:To study the ef ects of levosimendan on cardiac function and the levels of N terminal brain natriuretic peptide (NT-pro-BNP)in patients with chronic heatr failure(CHF)in acute aggravation status.Methods:55 patitents with CHF in acute aggravation status were randomly divided into routine treatment group(n=25),levosimendan group(n=30,received levosimendan based on rouG tine treatment),The cardiac function and the lvels of NT-pro-BNP wre observed in al groups before and after treatment.Result:The total ef ective rate in the levosimendan group was higher than the routine treatment groupl(P<0.05),and the SV and LVEF were significantly improved than routine treatment group (P<0.05);there were significant decreased in the levels of NT-pro-BNP in the levoG simendan group with the routine treatment group(P<0.05).Conclusion:Levosimendan can improve cardiac function CHF patients,and reduce the levels of NT-pro-BNP.