CAJ | 학술논문

肠道细菌在营养素代谢过程中起重要作用，进而影响机体整体代谢。小肠是氨基酸代谢的重要场所，对宿主蛋白质营养与肠道健康至关重要。然而，大量进入小肠的氨基酸在首过肠道代谢中被细菌转化代谢和利用。此外，小肠细菌对氨基酸的代谢呈现出区室化特征，这不仅表现在不同肠段上，还体现在层面上的差异。细菌对氨基酸的代谢产物包括二肽、多胺，它们能影响宿主肠道健康，细菌分解尿素再合成氨基酸的功能可能在一定程度上缓解宿主对氨基酸的需求。本文主要综述了小肠细菌在氨基酸首过肠道代谢中的作用与去路、对氨基酸代谢的区室化以及氨基酸代谢产物对宿主的影响。
장도세균재영양소대사과정중기중요작용，진이영향궤체정체대사。소장시안기산대사적중요장소，대숙주단백질영양여장도건강지관중요。연이，대량진입소장적안기산재수과장도대사중피세균전화대사화이용。차외，소장세균대안기산적대사정현출구실화특정，저불부표현재불동장단상，환체현재층면상적차이。세균대안기산적대사산물포괄이태、다알，타문능영향숙주장도건강，세균분해뇨소재합성안기산적공능가능재일정정도상완해숙주대안기산적수구。본문주요종술료소장세균재안기산수과장도대사중적작용여거로、대안기산대사적구실화이급안기산대사산물대숙주적영향。
Intestinal bacteria play important roles in nutrient metabolism, which furtherly affect body metabo-lism. Small intestine is the main region for amnio acids metabolism, and is critical to the host protein nutrition and gut health. However, large amount of amino acids entered into small intestine was degraded during the first-pass intestinal metabolism by bacteria. Amino acid metabolism in the small intestine is compartmentalized, not only segmented, but also layered. Amino acid metabolites, such as polyamine and dipeptide, are important for host gut health. Moreover, urea degradation and subsequent amino acid synthesis by the bacteria might be nutritionally valuable for the host. This article mainly reviewed the roles and out-ways in the first-pass intestinal metabolism of amino acids, metabolic compartments of amino acids, and the impacts of the metabolites on host health of small intestinal bacteria.