中国伤残医学
中國傷殘醫學
중국상잔의학
CHINESE JOURNAL OF TRAUMA AND DISABILITY MEDICINE
2015年
3期
44-46
,共3页
柔红霉素%长循环脂质体素%硫酸铵梯度法素%体外释放
柔紅黴素%長循環脂質體素%硫痠銨梯度法素%體外釋放
유홍매소%장순배지질체소%류산안제도법소%체외석방
Daunorubicin%Long circulating liposomes%Ammonium sulfate gradient method
目的：采用硫酸铵梯度法制备柔红霉素长循环脂质体，考察包封率的影响因素，并比较其与游离药物以及市售脂质体的体外释放行为。方法：采用硫酸铵梯度法制备柔红霉素长循环脂质体，以血浆蛋白为释放介质，研究其体外释放过程。结果：采用硫酸铵梯度法制备的柔红霉素脂质体包封率为93．43％，与游离药物以及市售脂质体比较，其在体外释放更加缓慢。结论：硫酸铵梯度法适合于制备柔红霉素长循环脂质体，制备的脂质体包封率高，体外释放具有明显的缓释作用。
目的：採用硫痠銨梯度法製備柔紅黴素長循環脂質體，攷察包封率的影響因素，併比較其與遊離藥物以及市售脂質體的體外釋放行為。方法：採用硫痠銨梯度法製備柔紅黴素長循環脂質體，以血漿蛋白為釋放介質，研究其體外釋放過程。結果：採用硫痠銨梯度法製備的柔紅黴素脂質體包封率為93．43％，與遊離藥物以及市售脂質體比較，其在體外釋放更加緩慢。結論：硫痠銨梯度法適閤于製備柔紅黴素長循環脂質體，製備的脂質體包封率高，體外釋放具有明顯的緩釋作用。
목적：채용류산안제도법제비유홍매소장순배지질체，고찰포봉솔적영향인소，병비교기여유리약물이급시수지질체적체외석방행위。방법：채용류산안제도법제비유홍매소장순배지질체，이혈장단백위석방개질，연구기체외석방과정。결과：채용류산안제도법제비적유홍매소지질체포봉솔위93．43％，여유리약물이급시수지질체비교，기재체외석방경가완만。결론：류산안제도법괄합우제비유홍매소장순배지질체，제비적지질체포봉솔고，체외석방구유명현적완석작용。
Objective:To prepare Daunorubicin ( DNR) hydrochloride long circulating liposomes by Ammonium sulfate gradient meth-od and evaluate the factors of encapsulation efficiency and its in vitro release .Methods:Ammonium sulfate gradient were set by dialysis to prepare DNR liposomes .The in vitro release behavior was investigated with plasma proteins as the release media .Results:Via ammonium sulfate gradient method , encapsulation efficiency of DNR liposomes was 93 .43%.the obtained DNR liposomes was released slower than the common liposomes and free Daunorubicin .Conclusion:Ammonium sulfate gradient method were qualified for preparing DNR hydro-chloride long circulating liposomes with high encapsulation efficiency , and delayed release in vitro .
