CAJ | 학술논문

目的：探讨阻塞性睡眠呼吸暂停低通气综合征发病过程中胶原纤维的形态学改变以及Ⅰ、Ⅲ型胶原纤维面积和总的胶原纤维面积与OSAHS患者各项临床指标的相关性。方法：回顾性分析成年男性8例非鼾症和14例鼾症组的一般情况，比较组织标本形态学染色，并测量Ⅰ、Ⅲ型胶原纤维面积和总的胶原纤维的面积。结果：通过实验我们发现OSAHS患者的软腭和悬雍垂结缔组织中的胶原纤维排列不规则，而且胶原纤维的面积和Ⅰ、Ⅲ型胶原纤维面积的增多，胶原纤维面积和Ⅰ、Ⅲ型胶原纤维面积与平均血氧饱和度、AHI、呼吸暂停指数存在相关性。结论：胶原纤维改变可能与OSAHS患者口咽弹性的降低相关。
목적：탐토조새성수면호흡잠정저통기종합정발병과정중효원섬유적형태학개변이급Ⅰ、Ⅲ형효원섬유면적화총적효원섬유면적여OSAHS환자각항림상지표적상관성。방법：회고성분석성년남성8례비한증화14례한증조적일반정황，비교조직표본형태학염색，병측량Ⅰ、Ⅲ형효원섬유면적화총적효원섬유적면적。결과：통과실험아문발현OSAHS환자적연악화현옹수결체조직중적효원섬유배렬불규칙，이차효원섬유적면적화Ⅰ、Ⅲ형효원섬유면적적증다，효원섬유면적화Ⅰ、Ⅲ형효원섬유면적여평균혈양포화도、AHI、호흡잠정지수존재상관성。결론：효원섬유개변가능여OSAHS환자구인탄성적강저상관。
Objective:This study focuses in the OSAHS pathogenesis of morphological changes and the area of typeⅠ,Ⅲcolla-gen and the total area of collagen fibers in patients with OSAHS of the clinical parameters .Methods:Retrospective analysis of OS-AHS and non OSAHS adult,To analysis of general condition,measure the area of collagen fiber and type Ⅰ, Ⅲcollagen fiber.Re-sults:In this study, we found that the connective tissue of soft palate and uvula of patients with OSAHS is irregular arrangement of collagen fibers, and the area of collagen fiber and typeⅠ,Ⅲcollagen fiber increased.The area of them is associated with the aver-age oxygen saturation, AHI and apnea index.Conclusion:Collagen fibers change may be associated with OSAHS patients of lower the oropharyngeal elasticity.