CAJ | 학술논문

采用高效液相色谱法测定五味子籽压榨油中的五味子醇甲、五味子甲素和五味子乙素，结果显示其含量分别为2．518％、0．577％和2．736％．五味子籽压榨油对小鼠的半数致死量（LD50）为10．8 g／kg，30 d小鼠喂养试验的血液生化指标均在正常范围内，表明五味子籽压榨油的毒性较低．通过建立小鼠酒精性肝损伤模型，并分别给予小鼠不同量的五味子籽压榨油以研究其对小鼠酒精肝损伤的保护作用，结果表明高剂量组与模型组呈显著性差异，证明五味子籽压榨油具有一定的肝保护作用．
채용고효액상색보법측정오미자자압자유중적오미자순갑、오미자갑소화오미자을소，결과현시기함량분별위2．518％、0．577％화2．736％．오미자자압자유대소서적반수치사량（LD50）위10．8 g／kg，30 d소서위양시험적혈액생화지표균재정상범위내，표명오미자자압자유적독성교저．통과건립소서주정성간손상모형，병분별급여소서불동량적오미자자압자유이연구기대소서주정간손상적보호작용，결과표명고제량조여모형조정현저성차이，증명오미자자압자유구유일정적간보호작용．
Using HPLC method for determination Schizandrol A,Schisandrin A and Schisandrin B in the pressure oil of Schisandrachinensis seed,the results showed that the content were 2.518%,0.577% and 2.736%,re-spectively.The LD50 was 10.8 g/kg,and the 30 days feeding test showed that the biochemical indexes of blood all were within normal range in mice,that results showed that the pressure oil of Schisandra chinensis seed had low toxicity.To establishing the mouse model of alcoholic liver inj ury evaluated the protective effect of liv-er inj ury with given different doses of pressure oil of Schisandra chinensis seed.The alcoholic liver inj ury model experiment results showed that the high dose group compared with model group had significant differ-ence,that demonstrate the pressure oil of Schisandra chinensis seed had particular effects on liver protection.