CAJ | 학술논문

脂肪源性干细胞因具有生物学特性稳定、来源广泛、取材方便、数量充足、易于培养扩增的优点，且在特定的诱导条件下可以分化为心肌细胞，有望成为细胞治疗的理想来源。诱导方法的选择，影响分化因素的研究已成为了细胞治疗领域研究的热点。本文就脂肪源性干细胞向心肌细胞诱导分化的方法和机制的研究进展进行综述。
지방원성간세포인구유생물학특성은정、래원엄범、취재방편、수량충족、역우배양확증적우점，차재특정적유도조건하가이분화위심기세포，유망성위세포치료적이상래원。유도방법적선택，영향분화인소적연구이성위료세포치료영역연구적열점。본문취지방원성간세포향심기세포유도분화적방법화궤제적연구진전진행종술。
Differentiation of Adipose-derived Stem Cells into Cardiomyocytes SHI Yuanyuan1, YANG Xiangqun2. 1 Company 2 of Clinical Medicine; Second Military Medical University, Shanghai 200433, China; 2 Department of Human Anatomy, Research Center of Regenerative Medicine, Second Military Medical University, Shanghai 200433, China. Corresponding author:YANG Xiangqun (E-mail:yangxgq@smmu.edu.cn).[Summary] The use of stem cells in the treatment of myocardial infarct has been strongly pursued in recent years. Due to their availability, feasibility, plasticity, and their potential to differentiate into cardiomyocytes at specific media, adipose-derived stem cells (ASCs) have become an ideal source of donor cells. A significant effort has gone into elucidating which factors and techniques influence this differentiation. The methods and mechanisms of differentiation of ASCs into cardiomyocytes were reviewed in this paper.