CAJ | 학술논문

目的：探讨香菇多糖和顺铂胸腔注射对肺癌术后胸腔积液患者的临床疗效及生活质量的影响。方法选取我院肺癌术后合并胸腔积液的患者60名，随机分为香菇多糖组与顺铂组，各30例，两组患者均采用胸腔置管闭式引流术，其中香菇多糖组给予香菇多糖8 mg胸腔内注射，顺铂组给予顺铂40 mg胸腔内注射，每周1次，共3次。比较两组患者治疗期间的临床疗效、不良反应，并评价两组患者的生活质量。结果香菇多糖组临床有效率为63.3％，与顺铂组比较，差异无统计学意义（P>0.05）；香菇多糖组生活质量缓解率为86.7％，明显高于顺铂组的50％，而不良反应发生率显著低于顺铂组，差异均有统计学意义（P<0.05）。结论使用香菇多糖胸腔注射治疗恶性胸腔积液，具有疗效肯定，不良反应发生率低，提升患者生活质量的明显优势。
목적：탐토향고다당화순박흉강주사대폐암술후흉강적액환자적림상료효급생활질량적영향。방법선취아원폐암술후합병흉강적액적환자60명，수궤분위향고다당조여순박조，각30례，량조환자균채용흉강치관폐식인류술，기중향고다당조급여향고다당8 mg흉강내주사，순박조급여순박40 mg흉강내주사，매주1차，공3차。비교량조환자치료기간적림상료효、불량반응，병평개량조환자적생활질량。결과향고다당조림상유효솔위63.3％，여순박조비교，차이무통계학의의（P>0.05）；향고다당조생활질량완해솔위86.7％，명현고우순박조적50％，이불량반응발생솔현저저우순박조，차이균유통계학의의（P<0.05）。결론사용향고다당흉강주사치료악성흉강적액，구유료효긍정，불량반응발생솔저，제승환자생활질량적명현우세。
Objective To investigate the curative effects of lentinan and cisplatin intrapleural injection in the treatment of postoperative lung cancer patients with pleural effusion. Methods Sixty postoperative lung cancer patients with pleural ef-fusion were selected from our hospital and divided into lentinan group (30 patients) and cisplatin group (30 patients). Both of the two groups were treated with closed drainage, followed by intrapleural injection of lentinan 8 mg for the lentinan group, cisplatin 40 mg for the cisplatin group, once a week, three times. After treatment, the effects and adverse reactions were com-pared between the two groups, and the quality of the life improvement rate was evaluated. Results The clinical efficiency of the lentinan group was 63.3%, which has no significant difference with the cisplatin group (P>0.05). In the lentinan group, 86.7%patients had their quality of life improved, while 50%in the cisplatin group did. The lentinan group had a higher improvement rate than the cisplatin group (P<0.05). The adverse effects rate of the lentinan group was significant lower than that of the cisplatin (P<0.05). Conclusion The intrapleural injection of lentinan had definite clinical effect, lower adverse reaction inci-dence and improved quality of life for postoperative lung cancer patients with pleural effusion.