CAJ | 학술논문

目的：观察依那普利联合川芎嗪治疗肺源性心脏病（肺心病）急性加重期的临床疗效。方法选取2013年1月—2014年4月都昌县人民医院收治的肺心病急性加重期患者78例，随机分为对照组和观察组，各39例。在常规治疗基础上，对照组患者给予依那普利治疗，观察组给予依那普利联合川芎嗪治疗，均治疗2周。比较两组患者治疗前后血液流变学指标及临床疗效。结果治疗前两组患者血浆黏度、全血黏度及红细胞比容比较，差异无统计学意义（P ＞0.05）；治疗后观察组患者上述指标均低于对照组（ P ＜0.05）。观察组患者总有效率为89.7％，高于对照组的69.2％（P ＜0.05）。结论依那普利联合川芎嗪治疗肺心病急性加重期疗效确切，可有效改善患者血液流变学和心肺功能。
목적：관찰의나보리연합천궁진치료폐원성심장병（폐심병）급성가중기적림상료효。방법선취2013년1월—2014년4월도창현인민의원수치적폐심병급성가중기환자78례，수궤분위대조조화관찰조，각39례。재상규치료기출상，대조조환자급여의나보리치료，관찰조급여의나보리연합천궁진치료，균치료2주。비교량조환자치료전후혈액류변학지표급림상료효。결과치료전량조환자혈장점도、전혈점도급홍세포비용비교，차이무통계학의의（P ＞0.05）；치료후관찰조환자상술지표균저우대조조（ P ＜0.05）。관찰조환자총유효솔위89.7％，고우대조조적69.2％（P ＜0.05）。결론의나보리연합천궁진치료폐심병급성가중기료효학절，가유효개선환자혈액류변학화심폐공능。
Objective To investigate the clinical effect of enalapril combined with ligustrazine on acute exacerbation of pulmonary heart disease. Methods From January 2013 to April 2014,a total of 78 patients with acute exacerbation of pulmona- ry heart disease in the People's Hospital of Duchang County were selected,and they were randomly divided into control group and observation group. Both groups given conventional therapy,and control group given extra enalapril,while observation group giv- en extra enalapril combined with ligustrazine,both groups treated for 2 weeks. Hemodynamic index before and after treatment, clinical effect between the two groups were compared. Results There was no significant differences of plasma viscosity,whole blood viscosity and hematocrit value between the two groups before treatment(P > 0. 05);but above index of observation group were lower than those of control group(P < 0. 05). The total effective rate of observation group was 89. 7% ,was higher than that of control group of 69. 2% (P < 0. 05). Conclusion Enalapril combined with ligustrazine has certain clinical effect on a- cute exacerbation of pulmonary heart disease,can improve heart function,lung function and hemorheology.