实用心脑肺血管病杂志
實用心腦肺血管病雜誌
실용심뇌폐혈관병잡지
PRACTICAL JOURNAL OF CARDIAC CEREBRAL PNEUMAL AND VASCULAR DISEASE
2014年
12期
33-35
,共3页
肺疾病,慢性阻塞性%肺心病%通气机,机械%C 反应蛋白质%利钠肽,脑
肺疾病,慢性阻塞性%肺心病%通氣機,機械%C 反應蛋白質%利鈉肽,腦
폐질병,만성조새성%폐심병%통기궤,궤계%C 반응단백질%리납태,뇌
Pulmonary disease,chronic obstructive%Pulmonary heart disease%Ventilators,mechanical%C reac- tive protein%Natriuretic peptide,brain
目的：探讨无创机械通气治疗慢性阻塞性肺疾病急性加重（AECOPD）并肺源性心脏病（肺心病）的疗效及对血浆 C 反应蛋白（CRP）和 B 型尿钠肽（BNP）水平的影响。方法选择2011年1月—2013年1月于都县人民医院收治的 AECOPD 并肺心病患者154例，将其随机分为对照组和观察组，各77例。对照组患者给予常规对症支持治疗，观察组患者在对照组基础上给予无创机械通气治疗，比较两组患者气促/胸闷、嗜睡及心率加快改善率，同时测定治疗前后血气分析指标（PaO2、PaCO2、SpO2）及血浆 CRP、BNP 水平。结果观察组患者气促/胸闷、嗜睡及心率加快改善率均高于对照组（P ＜0.05）。治疗前两组患者 PaO2、PaCO2、SpO2及血浆 CRP 和 BNP 水平比较，差异无统计学意义（P ＞0.05）；治疗后观察组患者 PaO2和 SpO2高于对照组，PaCO2及血浆 CRP 和 BNP 水平低于对照组（P ＜0.05）。结论无创机械通气能有效改善 AECOPD 并肺心病患者临床症状及血气分析指标，降低患者血浆 CRP、BNP水平。
目的：探討無創機械通氣治療慢性阻塞性肺疾病急性加重（AECOPD）併肺源性心髒病（肺心病）的療效及對血漿 C 反應蛋白（CRP）和 B 型尿鈉肽（BNP）水平的影響。方法選擇2011年1月—2013年1月于都縣人民醫院收治的 AECOPD 併肺心病患者154例，將其隨機分為對照組和觀察組，各77例。對照組患者給予常規對癥支持治療，觀察組患者在對照組基礎上給予無創機械通氣治療，比較兩組患者氣促/胸悶、嗜睡及心率加快改善率，同時測定治療前後血氣分析指標（PaO2、PaCO2、SpO2）及血漿 CRP、BNP 水平。結果觀察組患者氣促/胸悶、嗜睡及心率加快改善率均高于對照組（P ＜0.05）。治療前兩組患者 PaO2、PaCO2、SpO2及血漿 CRP 和 BNP 水平比較，差異無統計學意義（P ＞0.05）；治療後觀察組患者 PaO2和 SpO2高于對照組，PaCO2及血漿 CRP 和 BNP 水平低于對照組（P ＜0.05）。結論無創機械通氣能有效改善 AECOPD 併肺心病患者臨床癥狀及血氣分析指標，降低患者血漿 CRP、BNP水平。
목적：탐토무창궤계통기치료만성조새성폐질병급성가중（AECOPD）병폐원성심장병（폐심병）적료효급대혈장 C 반응단백（CRP）화 B 형뇨납태（BNP）수평적영향。방법선택2011년1월—2013년1월우도현인민의원수치적 AECOPD 병폐심병환자154례，장기수궤분위대조조화관찰조，각77례。대조조환자급여상규대증지지치료，관찰조환자재대조조기출상급여무창궤계통기치료，비교량조환자기촉/흉민、기수급심솔가쾌개선솔，동시측정치료전후혈기분석지표（PaO2、PaCO2、SpO2）급혈장 CRP、BNP 수평。결과관찰조환자기촉/흉민、기수급심솔가쾌개선솔균고우대조조（P ＜0.05）。치료전량조환자 PaO2、PaCO2、SpO2급혈장 CRP 화 BNP 수평비교，차이무통계학의의（P ＞0.05）；치료후관찰조환자 PaO2화 SpO2고우대조조，PaCO2급혈장 CRP 화 BNP 수평저우대조조（P ＜0.05）。결론무창궤계통기능유효개선 AECOPD 병폐심병환자림상증상급혈기분석지표，강저환자혈장 CRP、BNP수평。
Objective To investigate effect of noninvasive mechanical ventilation on acute exacerbation of chronic ob- structive pulmonary diseases(AECOPD)complicated with pulmonary heart disease and its impact on plasma levels of CRP and BNP. Methods From January 2011 to January 2013,154 AECOPD patients complicated with pulmonary heart disease were se- lected and divided into control group and observation group,each of 77 cases. Both groups given conventional symptomatic sup- portive treatment,and observation group given extra noninvasive mechanical ventilation. Improvement rate of anhelation/ chest dis- tress,somnolence and increased heart rate were compared between the two groups,blood gas analysis index including PaO2 , PaCO2 ,SpO2 and plasma levels of CRP and BNP were detected before and after treatment. Results The improvement rate of anhelation / chest distress,somnolence and increased heart rate of observation group was higher than that of control group,respec- tively(P < 0. 05). There was no significant differences of PaO2 ,PaCO2 ,SpO2 and plasma levels of CRP and BNP between the two groups before treatment,but PaO2 ,SpO2 of observation group were higher,PaCO2 ,plasma levels of CRP and BNP were lower than those of control group(P < 0. 05). Conclusion Noninvasive mechanical ventilation can effectively improve the clin- ical symptoms and blood gas analysis index,reduce the plasma levels of CRP and BNP.
