CAJ | 학술논문

目的探讨抗菌药物不良反应的原因并提出对策。方法对2012年1月至2013年12月本院门诊各科室2438张处方进行分类、统计分析，选取抗菌药物的处方468张，并对抗菌药物处方分析。结果本院各科室抗菌药物使用率为19.20%(468/2438)；抗菌药物使用前三位的科室为神经内科、消化内科和普外科，使用率分别为44.44%、30.56%、29.45%；抗菌药物以头孢菌素类、青霉素类、喹诺酮类为主，所占比例分为26.67%、16.67%、16.67%；给药途径主要为口服；不合理使用率为10.47%；诱发的不良反应主要表现为皮疹、皮肤瘙痒、腹泻、腹胀、心悸等。结论本院抗菌药物的临床使用基本合理，但仍存在部分不合理使用情况，医院应制定措施对抗生素的临床使用进行管理，提高抗菌药物临床应用的安全性。
목적탐토항균약물불량반응적원인병제출대책。방법대2012년1월지2013년12월본원문진각과실2438장처방진행분류、통계분석，선취항균약물적처방468장，병대항균약물처방분석。결과본원각과실항균약물사용솔위19.20%(468/2438)；항균약물사용전삼위적과실위신경내과、소화내과화보외과，사용솔분별위44.44%、30.56%、29.45%；항균약물이두포균소류、청매소류、규낙동류위주，소점비례분위26.67%、16.67%、16.67%；급약도경주요위구복；불합리사용솔위10.47%；유발적불량반응주요표현위피진、피부소양、복사、복창、심계등。결론본원항균약물적림상사용기본합리，단잉존재부분불합리사용정황，의원응제정조시대항생소적림상사용진행관리，제고항균약물림상응용적안전성。
Obj ective]To explore the cause of adverse reactions of antibacterial drugs,and to investigate the countermeasures.[Methods]Totally 2438 prescriptions of each outpatient department in our hospital from Jan.2012 to Dec.2013 were classified and analyzed by statistics.Among them,468 prescriptions of antibacte-rial drugs were selected and analyzed.[Results]The use rate of antibacterial drugs in each department of our hospital was 19.20%(468/2438).The first three departments of antibacterial drugs were neurology,gastro-enterology and general surgery departments,and the utilization rates were 44.44%,30.56% and 29.45%,re-spectively.Antibacterial drugs were mainly cephalosporins(26.67%),penicillins(16.67%)and quinolones (16.67%).The major administration route was oral administration.The irrational use rate was 10.47%.The main adverse reactions were rash,pruritus,diarrhea,bloating,heart palpitations and so on.[Conclusion]Clinical use of antibacterial drugs in our hospital is basically reasonable,but there are still parts of irrational usage.Hospitals should develop the measures in order to manage clinical use of antibiotics and increase the safety of clinical use of antibacterial drugs.