CAJ | 학술논문

目的探讨心房颤动(AF)与血清尿酸(UA)水平之间的相互关系。方法选择2009年3月至2012年7月本院住院及门诊的115例 AF患者作为研究组，同时期住院及门诊的106例非 AF患者作为对照组，记录两组患者的性别、年龄、心血管疾病相关危险因素、血 UA 水平、心脏彩超数据(包括左室射血分数、左房内径、左室舒张末期内径)、高敏C反应蛋白(hs-CRP)水平及用药史等。采用 Logistic回归分析 AF发生的危险因素，探讨血UA与AF之间的关系。结果研究组患者血清中UA、hs-CRP水平明显高于对照组，研究组左室射血分数显著低于对照组，左房内径、左室舒张末期内径显著高于对照组(均P<0.01)，多因素 Lo-gistic回归分析显示，高UA和hs-CRP水平与AF显著相关。结论 AF发生与血清高UA水平有一定关系。
목적탐토심방전동(AF)여혈청뇨산(UA)수평지간적상호관계。방법선택2009년3월지2012년7월본원주원급문진적115례 AF환자작위연구조，동시기주원급문진적106례비 AF환자작위대조조，기록량조환자적성별、년령、심혈관질병상관위험인소、혈 UA 수평、심장채초수거(포괄좌실사혈분수、좌방내경、좌실서장말기내경)、고민C반응단백(hs-CRP)수평급용약사등。채용 Logistic회귀분석 AF발생적위험인소，탐토혈UA여AF지간적관계。결과연구조환자혈청중UA、hs-CRP수평명현고우대조조，연구조좌실사혈분수현저저우대조조，좌방내경、좌실서장말기내경현저고우대조조(균P<0.01)，다인소 Lo-gistic회귀분석현시，고UA화hs-CRP수평여AF현저상관。결론 AF발생여혈청고UA수평유일정관계。
Objective]To explore the relationship between atrial fibrillation(AF)and serum uric acid (UA).[Methods]Totally 115 patients with AF in our hospital from March 2009 to July 2012 were chosen as the study group.At the same period,106 patients with non-AF in our hospital were chosen as the control group.Gender,age,risk factors associated with cardiovascular disease,serum UA,cardiac color ultrasonog-raphy data(left ventricular ejection fraction,left atrial diameter and left ventricular end-diastolic diameter), high-sensitivity C-reactive protein(Hs-CRP),medication history and so on in two groups were recorded.Lo-gistic regression was used to analyze the risk factors of AF.The relationship between serum UA and AF was discussed.[Results]Serum levels of UA and Hs-CRP in study group were obviously higher than those in con-trol group,and left ventricular ej ection fraction in study group was significantly lower than that in control group,and left atrial diameter and left ventricular end-diastolic diameter in study group were significantly higher than those in control group(all P <0.01).Multivariate logistic regression analysis showed that high levels of UA and Hs-CRP were significantly associated with AF.[Conclusion]The occurrence of AF has a certain correlation with high level of serum UA.