CAJ | 학술논문

目的探讨联合检测糖类抗原125(CA125)、癌胚抗原(CEA)、糖类抗原153(CA153)、人体绒膜促性腺激素(HCG)四种肿瘤标记物对卵巢癌的诊断价值。方法选取本院收治的35例卵巢癌患者为恶性组,35例良性卵巢肿瘤患者为良性组,35例健康体检者为对照组,观察比较三组血液中CA125、CEA、CA153、HCG的水平差异及其对卵巢肿瘤诊断的价值。结果①与良性组及对照组相比,恶性组 CA125、CEA、CA153、HCG四项指标均明显升高,且差异有显著性(P<0.05)；与对照组比较,良性组CA125与 HCG明显升高(P<0.05),CEA、CA153两组比较差异无显著性(P>0.05)。②恶性组四项肿瘤标记物阳性检出率明显高于良性组(P<0.05),对照组检出率为0；③与单项检测相比,联合检测在敏感性(94.3%)、阳性预测值(89.2%)、阴性预测值(94%)以及诊断效率(91.4%)有明显优势,其差异有显著性(P<0.05)。结论同时检测CA125、CEA、CA153、HCG诊断卵巢癌效率高,其对卵巢癌的防治有重要的临床意义,值得在临床上推广应用。
목적탐토연합검측당류항원125(CA125)、암배항원(CEA)、당류항원153(CA153)、인체융막촉성선격소(HCG)사충종류표기물대란소암적진단개치。방법선취본원수치적35례란소암환자위악성조,35례량성란소종류환자위량성조,35례건강체검자위대조조,관찰비교삼조혈액중CA125、CEA、CA153、HCG적수평차이급기대란소종류진단적개치。결과①여량성조급대조조상비,악성조 CA125、CEA、CA153、HCG사항지표균명현승고,차차이유현저성(P<0.05)；여대조조비교,량성조CA125여 HCG명현승고(P<0.05),CEA、CA153량조비교차이무현저성(P>0.05)。②악성조사항종류표기물양성검출솔명현고우량성조(P<0.05),대조조검출솔위0；③여단항검측상비,연합검측재민감성(94.3%)、양성예측치(89.2%)、음성예측치(94%)이급진단효솔(91.4%)유명현우세,기차이유현저성(P<0.05)。결론동시검측CA125、CEA、CA153、HCG진단란소암효솔고,기대란소암적방치유중요적림상의의,치득재림상상추엄응용。
Objective]To explore the value of combination detection of carbohydrate antigen 125(CA125), carcinoembryonic antigen(CEA),carbohydrate antigen 153(CA153)and human chorionic gonadotrophin(HCG)in the diagnosis of ovarian cancer.[Methods]A total of 35 patients with ovarian cancer in our hospital were chosen as malignant group,and 35 patients with benign ovarian tumor were chosen as benign group,and 35 healthy per-sons were chosen as control group.The levels of CA125,CEA,CA153 and HCG in blood among 3 groups were observed and compared,and their value in the diagnosis of ovarian tumors was discussed.[Results]Compared with benign group and control group,the levels of CA125,CEA,CA153 and HCG in malignant group were in-creased obviously,and there was significant difference(P <0.05).Compared with control group,the levels of CA125 and HCG in benign group were increased obviously(P<0.05),but there was no significance difference on CEA and CA153 between these two groups(P >0.05).The positive rate of four tumor markers in malignant group was obviously higher than that in benign group(P <0.05),and the positive rate in control group was 0. The sensitivity(94.3%),positive predictive value(89.2%),negative predictive value(94%)and diagnosis effi-ciency(9 1 .4%)of the combination detection were higher than those of four single marker detection,and there was significant difference(P<0.05).[Conclusion]The combination detection of CA125,CEA,CA153 and HCG for the diagnosis of ovarian cancer has high efficiency and is of great significance in the prevention of ovarian cancer. Therefore,it is worthy of clinical promotion.