CAJ | 학술논문

目的探讨右美托咪定对硬膜外麻醉后寒战和呼吸循环的影响。方法选取2013年1月至6月于本院进行择期手术 ASA Ⅰ~Ⅱ级患者60例,将其随机分为序贯法组和点斜法组各30例。序贯法组按照序贯法测定 ED50的要求进行测定；点斜法组按照点斜法测定 ED50的要求进行测定。观察记录给药前及给药第15、30、60 min平均动脉压(MBP)、心率(HR)、呼吸频率(RR)、脉搏血氧饱和度(SpO2)及寒战发生率。结果组内比较,两组患者给药前及给药15、30、60 min时 HR、MBP比较差异无统计学意义(P >0.05)；组间比较,两组患者各时间点 HR、MBP比较差异无统计学意义(P >0.05)。组内比较,两组患者给药前及给药15、30、60 min SpO2、RR比较差异无统计学意义(P>0.05)；组间比较,两组患者各时间点 SpO2、RR的差异无统计学意义(P>0.05)。两组患者在麻醉后寒战分级及发生率比较差异无统计学意义(P >0.05)。结论两种方法测定右美托咪定麻醉后寒战 ED50均为0.4μg/kg,两种方法均可以用于麻醉后寒战 ED50的测定。
목적탐토우미탁미정대경막외마취후한전화호흡순배적영향。방법선취2013년1월지6월우본원진행택기수술 ASA Ⅰ~Ⅱ급환자60례,장기수궤분위서관법조화점사법조각30례。서관법조안조서관법측정 ED50적요구진행측정；점사법조안조점사법측정 ED50적요구진행측정。관찰기록급약전급급약제15、30、60 min평균동맥압(MBP)、심솔(HR)、호흡빈솔(RR)、맥박혈양포화도(SpO2)급한전발생솔。결과조내비교,량조환자급약전급급약15、30、60 min시 HR、MBP비교차이무통계학의의(P >0.05)；조간비교,량조환자각시간점 HR、MBP비교차이무통계학의의(P >0.05)。조내비교,량조환자급약전급급약15、30、60 min SpO2、RR비교차이무통계학의의(P>0.05)；조간비교,량조환자각시간점 SpO2、RR적차이무통계학의의(P>0.05)。량조환자재마취후한전분급급발생솔비교차이무통계학의의(P >0.05)。결론량충방법측정우미탁미정마취후한전 ED50균위0.4μg/kg,량충방법균가이용우마취후한전 ED50적측정。
Obj ective]To explore the effect of dexmedetomidine on shivering,respiration and circulation after epidural anesthesia.[Methods]A total of 60 ASAⅠ~Ⅱ patients undergoing elective surgery in our hos-pital from Jan.2013 to June 2013 were chosen and randomly divided into sequential method group and point-slope method group with 30 patients in each group.ED50 of sequential method group was determined in accord-ance with the requirements of sequential method,while ED50 of point-slope method group was determined in accordance with the requirements of point-slope method.Mean arterial pressure(MBP),heart rate(HR),re-spiratory rate(RR),oxygen saturation(SpO2 )and the incidence of shivering before,15,30 and 60min after medication were observed and recorded.[Results]There was no significant difference in HR and MBP of two groups among before,15,30 and 60min after medication(P >0.05).There was no significant difference in HR and MBP at each time point between two groups(P>0.05).There was no significant difference in pPO2 and RR of two groups among before,15,30 and 60min after medication(P>0.05).There was no significant difference in SpO2 and RR at each time point between two groups(P>0.05).There was no significant differ-ence in the classification and incidence of shivering between two groups(P >0.05).[Conclusion]ED50 of shivering after dexmedetomidine anesthesia determined by both two methods are 0.4μg/kg.The two methods can be used to determine ED50 of shivering after anesthesia.