CAJ | 학술논문

目的探讨 Wnt2 b和β-catenin在胃癌中的表达及其临床意义。方法采用免疫组织化学染色检测48例胃癌组织和48例癌旁正常组织中 Wnt2b和β-catenin的表达,并分析其临床意义。结果 Wnt2b 和β-cate-nin在胃癌组织中的表达率分别为81.3%、66.7%；显著高于癌旁正常组织(12.5%和0%),差异具有统计学意义(χ2=45.553,P<0.05)；Wnt2b的表达与TNM分期、分化程度、淋巴结转移相关(P <0.05)；β-catenin的表达与TNM分期、分化程度、组织学类型、淋巴结转移和癌侵犯神经相关(P <0.05)；且 Wnt2 b 与β-catenin蛋白的表达呈显著正相关性(r=0.340,P<0.05)。结论 Wnt2b和β-catenin在胃癌的进展、分化、浸润和转移中起重要作用,是判断胃癌生物学行为的良好指标。
목적탐토 Wnt2 b화β-catenin재위암중적표체급기림상의의。방법채용면역조직화학염색검측48례위암조직화48례암방정상조직중 Wnt2b화β-catenin적표체,병분석기림상의의。결과 Wnt2b 화β-cate-nin재위암조직중적표체솔분별위81.3%、66.7%；현저고우암방정상조직(12.5%화0%),차이구유통계학의의(χ2=45.553,P<0.05)；Wnt2b적표체여TNM분기、분화정도、림파결전이상관(P <0.05)；β-catenin적표체여TNM분기、분화정도、조직학류형、림파결전이화암침범신경상관(P <0.05)；차 Wnt2 b 여β-catenin단백적표체정현저정상관성(r=0.340,P<0.05)。결론 Wnt2b화β-catenin재위암적진전、분화、침윤화전이중기중요작용,시판단위암생물학행위적량호지표。
Objective]To explore the expression and clinical significance of Wnt2b andβ-catenin in gastric carcino-ma.[Methods]The expressions of Wnt2b andβ-catenin in 48 gastric cancer tissues and 48 normal paracancerous tissues were detected by immunohistochemistry method.Clinical significance was analyzed.[Results]The expressions of Wnt2b andβ-catenin in gastric carcinoma tissues were 6 6 .7% and 3 5 .4% respectively,which were markedly higher than those in normal paracancerous tissues,and there were significant differences(χ2=45.553,P<0.05).The expression of Wnt2b was correlated with TNM stage,differentiation degree and lymph node metastasis(P<0.05).The positive expression ofβ-catenin in cancer tissues was obviously higher than that in normal paracancerous tissues(χ2=48.000,P<0.05),and correlated with TNM stage,differential degree,lymph node metastasis and nerve invasion(P<0.05).The protein ex-pression of Wnt2b was positively correlated with the protein expression ofβ-catenin(r=0.340,P<0.05).[Conclusion]Wnt2b andβ-catenin play important roles in the progression,differentiation,infiltration and lymph node metastasis of gastric carcinoma,and may be the good indicators for j udging the biological behavior of gastric carcinoma.