CAJ | 학술논문

志贺菌属（Shigella）是感染性腹泻的主要病原，对公共健康造成严重威胁，也给国家带来巨大的疾病负担。随着临床治疗上抗生素的不合理应用，志贺菌耐药问题越来越凸显，其中整合子-基因盒系统在其多重耐药性传播发展过程中起重要作用。以往单一针对志贺菌属整合子-基因盒系统的传播规律和流行特点的研究较少。本文拟对志贺菌属整合子系统及其耐药调控机制和耐药性的传播特点进行综述。
지하균속（Shigella）시감염성복사적주요병원，대공공건강조성엄중위협，야급국가대래거대적질병부담。수착림상치료상항생소적불합리응용，지하균내약문제월래월철현，기중정합자-기인합계통재기다중내약성전파발전과정중기중요작용。이왕단일침대지하균속정합자-기인합계통적전파규률화류행특점적연구교소。본문의대지하균속정합자계통급기내약조공궤제화내약성적전파특점진행종술。
Shigella is an important pathogen of infectious diarrhea. It is not only a huge burden of disease to the country, but also a serious threat to public health. With the unrational of antibiotics in clinical practice, the problem caused by the isolates of multidrug resistant Shigella has become more and more prominent. Integrons are ancient structures present in bacteria from the broader environment. However, there is still a significant lack of knowledge on how integron-gene cassettes in Shigella species spread and become epidemic. The authors aim to summarize the work of previous studies and make a deeper understanding on the epidemiology and molecular mechanism of integron-mediated antibiotic resistance in Shigella.