CAJ | 학술논문

目的：了解接受免费抗病毒治疗的AIDS患者的治疗效果和药物不良反应情况，为今后北京市AIDS防治工作提供依据。方法收集北京佑安医院艾滋病门诊2005年1月—2011年8月首次接受抗病毒治疗的731例AIDS患者临床相关信息，分析其治疗效果和药物不良反应情况。结果治疗开始后，病毒载量（viral load, VL）<50 copies/ml的患者所占比例逐渐增加，约为80%；治疗18个月时达到病毒学治疗成功的患者比例最高达91.1%。治疗后CD4+T淋巴细胞计数呈逐步上升趋势，治疗3年后达到平台期。在治疗过程中最常见的不良反应是消化道反应，药物不良反应也是治疗过程中换药的最主要原因。结论传统的抗反转录病毒治疗具有较好的抗病毒疗效，能显著降低患者血浆中VL，提高外周血CD4+T淋巴细胞计数；药物不良反应是治疗过程中换药的主要原因。
목적：료해접수면비항병독치료적AIDS환자적치료효과화약물불량반응정황，위금후북경시AIDS방치공작제공의거。방법수집북경우안의원애자병문진2005년1월—2011년8월수차접수항병독치료적731례AIDS환자림상상관신식，분석기치료효과화약물불량반응정황。결과치료개시후，병독재량（viral load, VL）<50 copies/ml적환자소점비례축점증가，약위80%；치료18개월시체도병독학치료성공적환자비례최고체91.1%。치료후CD4+T림파세포계수정축보상승추세，치료3년후체도평태기。재치료과정중최상견적불량반응시소화도반응，약물불량반응야시치료과정중환약적최주요원인。결론전통적항반전록병독치료구유교호적항병독료효，능현저강저환자혈장중VL，제고외주혈CD4+T림파세포계수；약물불량반응시치료과정중환약적주요원인。
Objective To investigate the therapeutic efficacy and drug-related adverse reactions of free antiretroviral treat-ment in naive AIDS patients, so as to provide evidence for the prevention and treatment of AIDS in Beijing. Methods Clinical data of 731 naive AIDS patients receiving antiretroviral therapy in Beijing You'an Hospital from Jan. 2005 to Aug. 2011 were collected, and the therapeutic efficacy and drug-related adverse reactions of the antiretroviral treatment were analyzed. Results The number of the patients with viral load less than 50 copies/ml increased gradually after the start of treatment, accounting for about 80%; viral load decreased and was undetectable in 91.1% of the patients at 18 months of treatment. CD4+T lymphocyte count increased gradu-ally during treatment, and maintained stable after 3 years of treatment. The most common drug-related adverse reactions were gas-trointestinal reactions. The main reason for switching regimens during treatment was drug-related adverse reaction. Conclusions The traditional antiretroviral therapy can achieve good antiviral efficacy, decreasing viral load in plasma and increasing CD4+T lympho-cyte count significantly. The main reason for switching regimens is drug-related adverse reaction.