江西医药
江西醫藥
강서의약
JIANGXI MEDICAL JOURNAL
2014年
12期
1414-1415,1548
,共3页
迎春花水提取物%镇静催眠%戊巴比妥钠
迎春花水提取物%鎮靜催眠%戊巴比妥鈉
영춘화수제취물%진정최면%무파비타납
Aqueous extract of Jasminum nudiflorum Lindl%Sedative and hypnotic%Pentobarbital sodium
目的：研究迎春花水提取物镇静催眠的影响。方法：取昆明种小鼠30只，随机分为生理盐水组、0.1g/kg、0.2g/kg迎春花水提取物组。采用抖笼法测定小鼠自发活动和对阈上、阈下剂量戊巴比妥钠小鼠睡眠时间的影响。结果：0.1g/kg、0.2g/kg的迎春花水提取物对小鼠自发活动具有明显抑制作用（P<0.05；P<0.01）。0.1g/kg、0.2g/kg的迎春花水提取物能显著（P<0.05；P<0.01）加速戊巴比妥钠的入睡时间和显著（P<0.05；P<0.01）延长戊巴比妥钠的睡眠时间，并与戊巴比妥钠有协同作用。结论：迎春花水提取物具有明显的抑制小鼠自发活动和镇静催眠作用。
目的：研究迎春花水提取物鎮靜催眠的影響。方法：取昆明種小鼠30隻，隨機分為生理鹽水組、0.1g/kg、0.2g/kg迎春花水提取物組。採用抖籠法測定小鼠自髮活動和對閾上、閾下劑量戊巴比妥鈉小鼠睡眠時間的影響。結果：0.1g/kg、0.2g/kg的迎春花水提取物對小鼠自髮活動具有明顯抑製作用（P<0.05；P<0.01）。0.1g/kg、0.2g/kg的迎春花水提取物能顯著（P<0.05；P<0.01）加速戊巴比妥鈉的入睡時間和顯著（P<0.05；P<0.01）延長戊巴比妥鈉的睡眠時間，併與戊巴比妥鈉有協同作用。結論：迎春花水提取物具有明顯的抑製小鼠自髮活動和鎮靜催眠作用。
목적：연구영춘화수제취물진정최면적영향。방법：취곤명충소서30지，수궤분위생리염수조、0.1g/kg、0.2g/kg영춘화수제취물조。채용두롱법측정소서자발활동화대역상、역하제량무파비타납소서수면시간적영향。결과：0.1g/kg、0.2g/kg적영춘화수제취물대소서자발활동구유명현억제작용（P<0.05；P<0.01）。0.1g/kg、0.2g/kg적영춘화수제취물능현저（P<0.05；P<0.01）가속무파비타납적입수시간화현저（P<0.05；P<0.01）연장무파비타납적수면시간，병여무파비타납유협동작용。결론：영춘화수제취물구유명현적억제소서자발활동화진정최면작용。
Objective To study the sedative and hypnotic effect of aqueous extract of Jasminum nudiflorum Lindl. Methods Thirty Kunming rats were divided into three groups including saline control group,0.1g/kg and 0.2g/kg of Jasminum nudiflorum Lindl. aqueous extract groups. Cage-shaking method was employed to observe the rats’locomotor activity,and how the pentobarbi-tal sodium at doses below and over the threshold affects the rat sleeping time. Results The rats’locomotor activity was significant-ly inhibited by administrating 0.1g/kg and 0.2g/kg of Jasminum nudiflorum Lindl. aqueous extract, the time to fall asleep was shorten and the sleeping time was prolonged after administrated pentobarbital sodium (P<0.05;P<0.01),which proved to have syn-ergistic effect with pentobarbital sodium. Conclusion The aqueous extract of Jasminum nudiflorum Lindl. inhibit the rats’locomo-tor activity significantly thus show obvious hypnotic effect.
