江西医药
江西醫藥
강서의약
JIANGXI MEDICAL JOURNAL
2014年
12期
1408-1410
,共3页
p16%IMP3%宫颈上皮内瘤变%宫颈鳞状细胞癌
p16%IMP3%宮頸上皮內瘤變%宮頸鱗狀細胞癌
p16%IMP3%궁경상피내류변%궁경린상세포암
p16%IMP3%Cervical intraepithelial neoplasia%Cervical squamous cell carcinoma
目的：研究p16和IMP3在宫颈上皮内瘤变（CIN）和鳞状细胞癌中的表达，探讨它们在CIN和鳞状细胞癌中的诊断价值。方法采用免疫组织化学方法检测20例慢性宫颈炎、97例CINⅠ、78例CINⅡ、68例CINⅢ和24例宫颈鳞状细胞癌中p16和IMP3的表达。结果 p16在慢性宫颈炎、CINⅠ、CINⅡ、CINⅢ和宫颈鳞状细胞癌阳性表达率分别为10%、55.7%、97.4%、97.1%和91.7%。p16在慢性宫颈炎与低级别CIN中的阳性表达率有显著性差异（P<0.01），在高级别CIN和宫颈鳞状细胞癌中的表达明显高于低级别CIN和慢性宫颈炎，有显著性差异（P<0.01）；而在高级别CIN和宫颈鳞状细胞癌中的阳性表达率没有差异（P>0.05）。IMP3在慢性宫颈炎和CINⅠ中不表达，在宫颈高级别上皮内瘤变（CINⅡ和CINⅢ）的阳性表达率分别为16.7%和23.5%，在宫颈鳞状细胞癌中的阳性表达率为91.7%，有显著性差异（P<0.01）。结论 p16的表达强度在宫颈上皮内瘤变到宫颈鳞状细胞癌的发展过程中逐步升高，IMP3表达主要在病变的晚期阶段。 p16和IMP3结合应用有助于宫颈上皮内瘤变和宫颈鳞状细胞癌的诊断和分级。
目的：研究p16和IMP3在宮頸上皮內瘤變（CIN）和鱗狀細胞癌中的錶達，探討它們在CIN和鱗狀細胞癌中的診斷價值。方法採用免疫組織化學方法檢測20例慢性宮頸炎、97例CINⅠ、78例CINⅡ、68例CINⅢ和24例宮頸鱗狀細胞癌中p16和IMP3的錶達。結果 p16在慢性宮頸炎、CINⅠ、CINⅡ、CINⅢ和宮頸鱗狀細胞癌暘性錶達率分彆為10%、55.7%、97.4%、97.1%和91.7%。p16在慢性宮頸炎與低級彆CIN中的暘性錶達率有顯著性差異（P<0.01），在高級彆CIN和宮頸鱗狀細胞癌中的錶達明顯高于低級彆CIN和慢性宮頸炎，有顯著性差異（P<0.01）；而在高級彆CIN和宮頸鱗狀細胞癌中的暘性錶達率沒有差異（P>0.05）。IMP3在慢性宮頸炎和CINⅠ中不錶達，在宮頸高級彆上皮內瘤變（CINⅡ和CINⅢ）的暘性錶達率分彆為16.7%和23.5%，在宮頸鱗狀細胞癌中的暘性錶達率為91.7%，有顯著性差異（P<0.01）。結論 p16的錶達彊度在宮頸上皮內瘤變到宮頸鱗狀細胞癌的髮展過程中逐步升高，IMP3錶達主要在病變的晚期階段。 p16和IMP3結閤應用有助于宮頸上皮內瘤變和宮頸鱗狀細胞癌的診斷和分級。
목적：연구p16화IMP3재궁경상피내류변（CIN）화린상세포암중적표체，탐토타문재CIN화린상세포암중적진단개치。방법채용면역조직화학방법검측20례만성궁경염、97례CINⅠ、78례CINⅡ、68례CINⅢ화24례궁경린상세포암중p16화IMP3적표체。결과 p16재만성궁경염、CINⅠ、CINⅡ、CINⅢ화궁경린상세포암양성표체솔분별위10%、55.7%、97.4%、97.1%화91.7%。p16재만성궁경염여저급별CIN중적양성표체솔유현저성차이（P<0.01），재고급별CIN화궁경린상세포암중적표체명현고우저급별CIN화만성궁경염，유현저성차이（P<0.01）；이재고급별CIN화궁경린상세포암중적양성표체솔몰유차이（P>0.05）。IMP3재만성궁경염화CINⅠ중불표체，재궁경고급별상피내류변（CINⅡ화CINⅢ）적양성표체솔분별위16.7%화23.5%，재궁경린상세포암중적양성표체솔위91.7%，유현저성차이（P<0.01）。결론 p16적표체강도재궁경상피내류변도궁경린상세포암적발전과정중축보승고，IMP3표체주요재병변적만기계단。 p16화IMP3결합응용유조우궁경상피내류변화궁경린상세포암적진단화분급。
Objective To study the expression of p16 and IMP3 in cervical imtraepithelial neoplasia and cervical squamous carcinoma,and to explore the diagnosis value of them. Methods The expression of p16 and IMP3 were detected by immunohisto-chemical staining in 20 cases of chronic cervicitis,97 cases of CINⅠ,78 cases of CINⅡ,68 cases of CINⅢand 24 cases of cer-vical squamous cell carcinoma. Results The positive rate of p16 expression in chronic cervicitis,CINⅠ,CINⅡ,CINⅢand cervi-cal squamous cell carcinoma was 10%,55.7%,97.4%,97.1% and 91.7%,respectively. The positive rate of p16 expression in chronic cervicitis and low-grade CIN was significant difference(P<0.01). The posive expression rate of p16 in high-grade CIN and cervical squamous cell carcinoma were significantly higher than chronic cervicitis and low-grade CIN ,the difference were signifi-cant (P<0.01). The posive expression rate of p16 in high-grade CIN and cervical squamous cell carcinoma compared with no cignificant difference (P>0.05). The negative of IMP3 expression in chronic cervicitis and low-grade CIN. The positive rate of IMP3 expression in CINⅡ,CINⅢ and cervical squamous cell carcinoma was 16.7%,23.5% and 91.7%,respectively. There were significant differences (P>0.01). Conclusion The expression levels of p16 were increased with cervical epithlelial malignant transformation progress and the expression of IMP3 was the lately event of development of cervical squamous carcinoma. Using p16 and IMP3 may be helpful for the diagnosis and of grade of CIN and cervical squamous cell carcinoma.
