CAJ | 학술논문

丝裂原活化蛋白激酶/细胞外调节蛋白激酶(MAPK/ERK)信号通路参与调控肿瘤的生长和转移，而肿瘤的生长需要新生血管的维持，肿瘤血管的生成需要血管内皮细胞的参与，包括内皮细胞的增殖、迁移、侵袭。作为Ras/Raf/MEK/ERK途径是该网络信号的核心，本文就MAPK/ERK信号通路中各环节与肿瘤血管新生的联系做一综述，进一步研究其在抑制肿瘤生长方面做出推论。
사렬원활화단백격매/세포외조절단백격매(MAPK/ERK)신호통로삼여조공종류적생장화전이，이종류적생장수요신생혈관적유지，종류혈관적생성수요혈관내피세포적삼여，포괄내피세포적증식、천이、침습。작위Ras/Raf/MEK/ERK도경시해망락신호적핵심，본문취MAPK/ERK신호통로중각배절여종류혈관신생적련계주일종술，진일보연구기재억제종류생장방면주출추론。
MAPK/ERK signal pathway involves in the regulation of tumor growth and metastasis, and tumor growth cannot do without angiogenesis. Tumor angiogenesis requires the participation of vascular endothelial cells, including endothelial cell proliferation, migration and invasion. So as the core of this network signal: Ras/Raf/MEK/ERK path-way, this paper focus on the modulation between various MAPK/ERK signaling links and tumor angiogenesis, for mak-ing further study of the inferred in inhibiting tumor growth.