中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2015年
1期
79-82
,共4页
厌食症%儿童%枯草杆菌二联活菌颗粒%神经肽Y%肿瘤坏死因子-α
厭食癥%兒童%枯草桿菌二聯活菌顆粒%神經肽Y%腫瘤壞死因子-α
염식증%인동%고초간균이련활균과립%신경태Y%종류배사인자-α
Anorexia%Children%Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines%Neuropeptide Y%Tumor Necrosis Factor-α
目的：探讨枯草杆菌二联活菌颗粒对厌食症患儿血清神经肽Y(NPY)和肿瘤坏死因子-α(TNF-α)水平影响及疗效。方法选取2012年6月~2014年6月在浙江省嘉兴市妇幼保健院儿童厌食症患者86例，采用随机数字表将其分为观察组(43例)和对照组(43例)。两组患儿均予以纠正患儿不良饮食习惯、健胃消食药和葡萄糖酸锌等常规治疗。观察组患儿加用枯草杆菌二联活菌颗粒1.0 g/次，2次/d，温开水冲服。疗程为6周。对照组患儿除不使用枯草杆菌二联活菌颗粒外余治疗基本同观察组。观察并记录两组患儿治疗前和治疗6周后血清NPY和TNF-α水平的变化，并比较其治疗后的临床效果及药物不良反应。结果治疗6周后，两组患儿血清NPY和TNF-α水平[观察组：(45.53±7.82)pg/mL，(10.24±2.74)mmol/L；对照组：(37.39±7.53)pg/mL，(8.19±2.13)mmol/L]较治疗前[观察组：(32.17±5.18)pg/mL，(6.82±1.76)mmol/L；对照组：(32.79±4.23)pg/mL，(7.03±1.54)mmol/L]明显上升(t =2.89、3.12、2.31、2.45，P<0.05或P<0.01)，且观察组上升程度较对照组更明显(t =2.19、2.24，P<0.05)；同时观察组患儿临床总有效率(93.02%)较对照组(76.74%)更佳(χ2=4.44，P<0.05)。两组患儿治疗中无明显的药物不良反应发生。结论枯草杆菌二联活菌颗粒治疗儿童厌食症的效果较确切，且安全性较好，其作用机制可能与其升高血清NPY和TNF-α水平，提高患儿的食欲密切相关。
目的：探討枯草桿菌二聯活菌顆粒對厭食癥患兒血清神經肽Y(NPY)和腫瘤壞死因子-α(TNF-α)水平影響及療效。方法選取2012年6月~2014年6月在浙江省嘉興市婦幼保健院兒童厭食癥患者86例，採用隨機數字錶將其分為觀察組(43例)和對照組(43例)。兩組患兒均予以糾正患兒不良飲食習慣、健胃消食藥和葡萄糖痠鋅等常規治療。觀察組患兒加用枯草桿菌二聯活菌顆粒1.0 g/次，2次/d，溫開水遲服。療程為6週。對照組患兒除不使用枯草桿菌二聯活菌顆粒外餘治療基本同觀察組。觀察併記錄兩組患兒治療前和治療6週後血清NPY和TNF-α水平的變化，併比較其治療後的臨床效果及藥物不良反應。結果治療6週後，兩組患兒血清NPY和TNF-α水平[觀察組：(45.53±7.82)pg/mL，(10.24±2.74)mmol/L；對照組：(37.39±7.53)pg/mL，(8.19±2.13)mmol/L]較治療前[觀察組：(32.17±5.18)pg/mL，(6.82±1.76)mmol/L；對照組：(32.79±4.23)pg/mL，(7.03±1.54)mmol/L]明顯上升(t =2.89、3.12、2.31、2.45，P<0.05或P<0.01)，且觀察組上升程度較對照組更明顯(t =2.19、2.24，P<0.05)；同時觀察組患兒臨床總有效率(93.02%)較對照組(76.74%)更佳(χ2=4.44，P<0.05)。兩組患兒治療中無明顯的藥物不良反應髮生。結論枯草桿菌二聯活菌顆粒治療兒童厭食癥的效果較確切，且安全性較好，其作用機製可能與其升高血清NPY和TNF-α水平，提高患兒的食欲密切相關。
목적：탐토고초간균이련활균과립대염식증환인혈청신경태Y(NPY)화종류배사인자-α(TNF-α)수평영향급료효。방법선취2012년6월~2014년6월재절강성가흥시부유보건원인동염식증환자86례，채용수궤수자표장기분위관찰조(43례)화대조조(43례)。량조환인균여이규정환인불량음식습관、건위소식약화포도당산자등상규치료。관찰조환인가용고초간균이련활균과립1.0 g/차，2차/d，온개수충복。료정위6주。대조조환인제불사용고초간균이련활균과립외여치료기본동관찰조。관찰병기록량조환인치료전화치료6주후혈청NPY화TNF-α수평적변화，병비교기치료후적림상효과급약물불량반응。결과치료6주후，량조환인혈청NPY화TNF-α수평[관찰조：(45.53±7.82)pg/mL，(10.24±2.74)mmol/L；대조조：(37.39±7.53)pg/mL，(8.19±2.13)mmol/L]교치료전[관찰조：(32.17±5.18)pg/mL，(6.82±1.76)mmol/L；대조조：(32.79±4.23)pg/mL，(7.03±1.54)mmol/L]명현상승(t =2.89、3.12、2.31、2.45，P<0.05혹P<0.01)，차관찰조상승정도교대조조경명현(t =2.19、2.24，P<0.05)；동시관찰조환인림상총유효솔(93.02%)교대조조(76.74%)경가(χ2=4.44，P<0.05)。량조환인치료중무명현적약물불량반응발생。결론고초간균이련활균과립치료인동염식증적효과교학절，차안전성교호，기작용궤제가능여기승고혈청NPY화TNF-α수평，제고환인적식욕밀절상관。
Objective To discuss the influence and effect of Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines for serum neuropeptide Y (NPY) and tumor necrosis factor (TNF)-αlevels of children with anorexia. Methods Eighty six cases of children with anorexia collected by Jiaxing Maternal and Child Care Service Center from June 2012 to June 2014 were selected, and divided into observation group (43 cases) and control group (43 cases) by random number table. The patients in two groups were given routine medical treatment such like adjustment of poor eating habit, Jianwei Xiaoshi Tablets, Zinc Gluconate and etc. The children in observation group were additionally given Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines 1.0 g per time, twice a day, with warm boiled water for 6 weeks. Except for Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines, the children in control group were given the same medical treatment as that in observation group. The changes of serum NPY and TNF-α levels of children in two groups before and 6 weeks after medical treatment were observed and recorded, and the curative effect and drug adverse reactions were compared as well. Results After treatment for 6 weeks, the levels of serum NPY and TNF-αof children in two groups [observation group:(45.53±7.82) pg/mL, (10.24±2.74) mmol/L;control group:(37.39±7.53) pg/mL, (8.19±2.13) mmol/L] were obviously rose than before [observation group:(32.17±5.18) pg/mL, (6.82±1.76) mmol/L;control group:(32.79±4.23) pg/mL, (7.03±1.54) mmol/L] (t =2.89, 3.12, 2.31, 2.45, P< 0.05 or P< 0.01), and the rising rate of children in observation group was much higher than that in control group (t = 2.19, 2.24, P< 0.05). The total clinical efficiency of children in observation group was 93.02%, which was much higher than that in control group (76.74%) (χ2=4.44, P< 0.05), with no obvious drug adverse reactions during treatment. Conclusion Combined Bacillus Subtilis and Enterococcus Faecium Granules with Multivitamines has favorable curative effect and high security on children with anorexia, whose mechanism of action has close effect on increasing serum NPY and TNF-αlevels and improving the appetite in children.
