CAJ | 학술논문

固有无序蛋白是一类缺乏稳定结构的特殊蛋白质，在生命活动中行使重要的生物学功能，与人类重大疾病密切相关。通过将混沌可视化模型及氨基酸分类应用于蛋白质序列分析中，系统研究固有无序蛋白序列的多聚体特征。结果表明，运用CGR方法可以直观分析固有无序蛋白序列相关信息，也可以定量描述相关序列特征。对固有无序蛋白二聚体氨基酸的具体研究表明，固有无序蛋白对二聚体氨基酸的使用具有明显偏好性，为今后蛋白序列多聚体特征研究提供良好的研究思路。
고유무서단백시일류결핍은정결구적특수단백질，재생명활동중행사중요적생물학공능，여인류중대질병밀절상관。통과장혼돈가시화모형급안기산분류응용우단백질서렬분석중，계통연구고유무서단백서렬적다취체특정。결과표명，운용CGR방법가이직관분석고유무서단백서렬상관신식，야가이정량묘술상관서렬특정。대고유무서단백이취체안기산적구체연구표명，고유무서단백대이취체안기산적사용구유명현편호성，위금후단백서렬다취체특정연구제공량호적연구사로。
Intrinsically disordered proteins (IDPs)is a kind of proteins which lack stable structures and have important biological functions in biological activities.It is closely related to many significant human diseases.In this paper,we studied the sequence characteristics of IDPs sequence systematically using the chaos game representation model.The results show that the CGR method can display the intrinsic features of IDPs visually.Meanwhile it can also describe the sequence features of IDPs quantitatively.Further studies based on amino acids classifications show that IDPs have obvious preference in the use of the dimer acids.Therefore,this work may provide efficient tools for future research of IDPs.