CAJ | 학술논문

采用高效液相色谱法,研究了以50 mg/kg (体质量)的剂量在口灌给药条件下,复方磺胺甲噁唑(甲氧苄啶.磺胺甲噁唑=1.5)在松浦镜鲤Cyprinus carpio Songpu体内的药动学与残留消除规律。结果表明：单次给药后,甲氧苄啶在血浆和肌肉中的药时关系符合一级吸收一室开放模型,在肝胰脏和肾中的药时关系符合一级吸收二室开放模型,磺胺甲噁唑在血浆、肌肉、肝胰脏和肾中的药时关系符合一级吸收二室开放模型；每天一次连续5 d给药后,甲氧苄啶于第15天开始低于0·05 mg/kg,磺胺甲噁唑于第9天开始低于0·10 mg/kg。研究表明,在本试验条件下,建议休药期不低于15 d。
채용고효액상색보법,연구료이50 mg/kg (체질량)적제량재구관급약조건하,복방광알갑오서(갑양변정.광알갑오서=1.5)재송포경리Cyprinus carpio Songpu체내적약동학여잔류소제규률。결과표명：단차급약후,갑양변정재혈장화기육중적약시관계부합일급흡수일실개방모형,재간이장화신중적약시관계부합일급흡수이실개방모형,광알갑오서재혈장、기육、간이장화신중적약시관계부합일급흡수이실개방모형；매천일차련속5 d급약후,갑양변정우제15천개시저우0·05 mg/kg,광알갑오서우제9천개시저우0·10 mg/kg。연구표명,재본시험조건하,건의휴약기불저우15 d。
The pharmacokinetics and residues of compound sulfamethoxazole ( trimethoprim :sulfamethoxazole=1 :5 ) was studied in Songpu mirror carp Cyprinus carpio Songpu exposed to oral administration at 50 mg/kg body weight by means of HPLC. The results showed that the concentrations versus time of trimethoprim ( TMP) in plasma and muscle were well described by one-department open model with first-order absorption. However, the concen-trations versus time of trimethoprim in hepatopancreas and kidney were well described by two-department open model with first-order absorption after a single oral administration. The concentrations versus time of sulfamethox-azole( SMZ) in plasma, muscle, hepatopancreas and kidney were well described by a two-department open model with first-order absorption. The residues in Songpu mirror carp by oral administration for 5 d once a day was found to be less than the maximum residue limit (MRL) (0. 05 mg/kg) at the day 15 for TMP and to be less than MRL (0. 10 mg/kg) at the day 9 for SMZ. The findings indicate that the withdrawal time should be 15 d after adminis-tration in these conditions.