CAJ | 학술논문

目的：探讨长期住院慢性精神分裂症患者血清尿酸的变化。方法采用单纯随机抽样方法抽取2014年在苏州民康医院住院的年龄≥55岁的符合《中国精神障碍分类与诊断标准（第3版）》（ CCMD-3）诊断标准的慢性精神分裂症患者110例作为观察组；随机抽取2014年苏州市金阊区未患精神分裂症的年龄≥55岁的正常老年人500例作为对照组。采用尿酸酶法进行尿酸测定。结果慢性精神分裂症患者高尿酸血症的检出率随着年龄与病程的增加而呈上升趋势，男性明显，差异有统计学意义（χ2＝7.73，P﹤0.05）。精神分裂症患者血清尿酸浓度均值低于对照组，差异有统计学意义（ t＝-3.557，P﹤0.05）。结论慢性精神分裂症患者存在尿酸代谢异常。
목적：탐토장기주원만성정신분렬증환자혈청뇨산적변화。방법채용단순수궤추양방법추취2014년재소주민강의원주원적년령≥55세적부합《중국정신장애분류여진단표준（제3판）》（ CCMD-3）진단표준적만성정신분렬증환자110례작위관찰조；수궤추취2014년소주시금창구미환정신분렬증적년령≥55세적정상노년인500례작위대조조。채용뇨산매법진행뇨산측정。결과만성정신분렬증환자고뇨산혈증적검출솔수착년령여병정적증가이정상승추세，남성명현，차이유통계학의의（χ2＝7.73，P﹤0.05）。정신분렬증환자혈청뇨산농도균치저우대조조，차이유통계학의의（ t＝-3.557，P﹤0.05）。결론만성정신분렬증환자존재뇨산대사이상。
Objective To investigate the changes of serum uric acid of Long-term hospitalized patients with chronic schizophre-nia. Methods Random sampling method was used to choose the subject. 110 cases of chronic schizophrenia patients older than 55 years old hospitalized in Minkang hospital of Suzhou in 2014 were classified as observation group. Then 500 cases of old people older than 55 years old without mental illness who attended the elderly health examination of Suzhou Jinchang district hospital in 2014 were classified as control group. We used the enzymatic method for determination of uric acid. Results Especially men,the prevalence of hyperuricemia in patients with chronic schizophrenia increased with the rising age and duration. And there was statistically significant difference(χ2 =7. 73,P﹤0. 05). Serum uric acid concentration of patients with chronic schizophrenia were significantly lower than con-trol group. There was statistically significant difference(t= -3. 557,P﹤0. 05). Conclusion The patients with chronic schizophrenia have the abnormal of the serum uric acid metabolism.