CAJ | 학술논문

目的：探讨应用金乌骨通对预防绝经女性骨质疏松性骨折发生的影响。方法采用随机对照研究。方法：将176例绝经女性骨质疏松症患者随机分为试验组（n=90）和对照组（n=86）。试验组：应用金乌骨通胶囊口服，每次3粒，每日3次，连用1年。对照组服用安慰剂胶囊，每次3粒，每日3次，连用一年。所有受试者均每日服用钙尔奇D600mg。测定两组患者治疗前后腰椎骨密度（BMD），观察两组骨折、骨痛及平衡能力等情况。结果：与干预前相比，两组患者的腰椎BMD均有显著上升、骨痛症状均有明显缓解，但试验组与对照组相比，差异有统计学意义（P＜0.05）；用药干预后患者骨折发生率与跌倒次数均低于对照组。用药干预后患者的平衡能力较前明显增强(P＜0.05)，而对照组无显著变化。结论：金乌骨通可明显提高绝经女性骨密度，改善骨痛程度，同时平衡能力和跌倒次数也明显改善。
목적：탐토응용금오골통대예방절경녀성골질소송성골절발생적영향。방법채용수궤대조연구。방법：장176례절경녀성골질소송증환자수궤분위시험조（n=90）화대조조（n=86）。시험조：응용금오골통효낭구복，매차3립，매일3차，련용1년。대조조복용안위제효낭，매차3립，매일3차，련용일년。소유수시자균매일복용개이기D600mg。측정량조환자치료전후요추골밀도（BMD），관찰량조골절、골통급평형능력등정황。결과：여간예전상비，량조환자적요추BMD균유현저상승、골통증상균유명현완해，단시험조여대조조상비，차이유통계학의의（P＜0.05）；용약간예후환자골절발생솔여질도차수균저우대조조。용약간예후환자적평형능력교전명현증강(P＜0.05)，이대조조무현저변화。결론：금오골통가명현제고절경녀성골밀도，개선골통정도，동시평형능력화질도차수야명현개선。
[ABSTRACT]Objective:To study the clinical influence of jiwugutonjioanang in prevention of vertebral osteoporotic compression fractures with postmenopausal. Methods: 176 postmenopausal women who suffered with osteorotic compression fractures were randomly divided into two groups, patients in the treatment group were given jiwugutongjiaonang (three pills tid),lasting one year and the control group were given anwejijiaonang (three pills tid), lasting one year. All the patients took gaierqi D (600mg) everyday, evaluating all the patients's bone mineral density before and after the treatment, observing the conditions of the pain relief, the ability of balance and fracture healing. Results: The vertebras BMD of patients in two groups increased markedly and the pain of bone were obviously relived comparing to the treatment before. However, there were significant differences between the treatment group and control group (P<0.5); the proportion of recurrence of fracture and the times of falling were reducing compared with the control group. The patients's ability of balance increasing obviously after treatment (P<0.5) but the control group not. Conclusion:Jinwugutongjiaonang could increase the bone density of the postmenopausal women, improve the degree of bone pain, develop the ability of balance and descend the times of falling.