CAJ | 학술논문

目的：观察甘露聚糖肽联合顺铂胸腔内灌注治疗对80例恶性胸腔积液的疗效及安全性。方法：将经病理学或细胞学检查确诊的80例恶性肿瘤并恶性胸腔积液患者随机分为两组，试验组(甘露聚糖肽+顺铂)胸腔内注入生理盐水20ml+顺铂60mg，生理盐水20ml+甘露聚糖肽30mg；对照组(顺铂)胸腔内注入生理盐水20ml+顺铂60mg，两组给药方法相同，均为每周1次，共4次。结果：试验组近期疗效显著优于对照组(总有效率85% vs 52.5%，P=0.03)；试验组KPS评分改善率85%，对照组为55%，有显著差异(P=0.03)；对照组出现3例骨髓抑制，试验组无骨髓抑制，具有极显著差异(P＜0.01)；试验组胸痛2例，对照组5例，试验组恶心呕吐1例，对照组为4例，均有显著差异(P＜0.05)。结论：甘露聚糖肽联合顺铂胸腔内灌注治疗恶性胸腔积液，近期疗效、KPS评分显著优于单独使用顺铂，并显著减轻了顺铂的骨髓抑制、胸痛及恶性呕吐等不良反应。
목적：관찰감로취당태연합순박흉강내관주치료대80례악성흉강적액적료효급안전성。방법：장경병이학혹세포학검사학진적80례악성종류병악성흉강적액환자수궤분위량조，시험조(감로취당태+순박)흉강내주입생리염수20ml+순박60mg，생리염수20ml+감로취당태30mg；대조조(순박)흉강내주입생리염수20ml+순박60mg，량조급약방법상동，균위매주1차，공4차。결과：시험조근기료효현저우우대조조(총유효솔85% vs 52.5%，P=0.03)；시험조KPS평분개선솔85%，대조조위55%，유현저차이(P=0.03)；대조조출현3례골수억제，시험조무골수억제，구유겁현저차이(P＜0.01)；시험조흉통2례，대조조5례，시험조악심구토1례，대조조위4례，균유현저차이(P＜0.05)。결론：감로취당태연합순박흉강내관주치료악성흉강적액，근기료효、KPS평분현저우우단독사용순박，병현저감경료순박적골수억제、흉통급악성구토등불량반응。
[ABSTRACT]Objective: To observe the efficacy and safety of Mannatide combined with cisplatin in the treatment of malignant pleural effusion.Methods:80 cases of malignant and malignant pleural effusion confirmed by pathology or cytology were randomly divided into two groups. The treatment group (Mannatide+cisplatin) were given saline 20ml+cisplatin 60mg,saline 20ml+30mg Mannatide intrapleurally.The control group(cisplatin) were given saline 20ml+cisplatin 60mg intrapleurally,weekly for a total of 4times.Results:The short-term efficacy of the treatment group was significantly better than the control group (total efficiency ratio 85% vs 52.5%,P=0.03);the improvement rate of KPS in the treatment group was 85%,while that in the control group was 55%,with a significant difference (P=0.03).There were three cases of bone marrow suppression in the control group,while there were none in the treatment group with a very significant difference (P<0.01).There were two cases of chest pain in the treatment group and five cases in the control group.There were one case of malignant vomiting in the treatment group and 4cases in the control group,with significant difference (P<0.05). Conclusion: The infusion therapy that Mannatide combined with cisplatin in the treatment of malignant pleural effusion can improve the short-term efficacy, KPS score using cisplatin alone,and can reduce chest pain, nausea, vomiting and other adverse reactions caused by cisplatin myelosuppression significantly.