中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2014年
12期
1475-1476
,共2页
吴翊群%陈明%叶丽华%卜新华
吳翊群%陳明%葉麗華%蔔新華
오익군%진명%협려화%복신화
围绝经期综合征%香芍颗粒%克龄蒙
圍絕經期綜閤徵%香芍顆粒%剋齡矇
위절경기종합정%향작과립%극령몽
Perimenopausal syndrome%Xiang Shao particle%Climen
目的：评价中成药香芍颗粒治疗围绝经期综合征疗效及卵巢功能状态对其影响。方法：采用随机对照研究2个月，患者随机分为香芍颗粒组，香芍颗粒一次1袋，一日3次，8周为一疗程。克龄蒙组，克龄蒙(前11片含戊酸雌二醇2mg/片，后10片并含醋酸环丙孕酮1mg/片)，连服21天。停药后等月经来潮，在月经来潮的第5天开始口服下一疗程药物，连续用药两个疗程。研究期间患者记录症状、乳胀等，随访时进行改良Kupperman症状(K)评分评估围绝经期症状，检测血清雌二醇(E2)、卵泡刺激素（FSH），评估治疗反应。结果：治疗后，香芍颗粒组和克龄蒙组K评分临床有效率分别为76.7%和80%，潮热评分有效率分别为90%和93.33%，两组之间均无显著性差异(P＞0.05)。香芍颗粒组血清FSH水平显著下降(P＜0.01)，E2水平呈显著增加(P＜0.01)。但变化幅度略低于克龄蒙组(P＞0.05)。两组均无严重不良反应。结论：香芍颗粒对改善围绝经期综合征症状有效，安全性好，无严重不良反应。
目的：評價中成藥香芍顆粒治療圍絕經期綜閤徵療效及卵巢功能狀態對其影響。方法：採用隨機對照研究2箇月，患者隨機分為香芍顆粒組，香芍顆粒一次1袋，一日3次，8週為一療程。剋齡矇組，剋齡矇(前11片含戊痠雌二醇2mg/片，後10片併含醋痠環丙孕酮1mg/片)，連服21天。停藥後等月經來潮，在月經來潮的第5天開始口服下一療程藥物，連續用藥兩箇療程。研究期間患者記錄癥狀、乳脹等，隨訪時進行改良Kupperman癥狀(K)評分評估圍絕經期癥狀，檢測血清雌二醇(E2)、卵泡刺激素（FSH），評估治療反應。結果：治療後，香芍顆粒組和剋齡矇組K評分臨床有效率分彆為76.7%和80%，潮熱評分有效率分彆為90%和93.33%，兩組之間均無顯著性差異(P＞0.05)。香芍顆粒組血清FSH水平顯著下降(P＜0.01)，E2水平呈顯著增加(P＜0.01)。但變化幅度略低于剋齡矇組(P＞0.05)。兩組均無嚴重不良反應。結論：香芍顆粒對改善圍絕經期綜閤徵癥狀有效，安全性好，無嚴重不良反應。
목적：평개중성약향작과립치료위절경기종합정료효급란소공능상태대기영향。방법：채용수궤대조연구2개월，환자수궤분위향작과립조，향작과립일차1대，일일3차，8주위일료정。극령몽조，극령몽(전11편함무산자이순2mg/편，후10편병함작산배병잉동1mg/편)，련복21천。정약후등월경래조，재월경래조적제5천개시구복하일료정약물，련속용약량개료정。연구기간환자기록증상、유창등，수방시진행개량Kupperman증상(K)평분평고위절경기증상，검측혈청자이순(E2)、란포자격소（FSH），평고치료반응。결과：치료후，향작과립조화극령몽조K평분림상유효솔분별위76.7%화80%，조열평분유효솔분별위90%화93.33%，량조지간균무현저성차이(P＞0.05)。향작과립조혈청FSH수평현저하강(P＜0.01)，E2수평정현저증가(P＜0.01)。단변화폭도략저우극령몽조(P＞0.05)。량조균무엄중불량반응。결론：향작과립대개선위절경기종합정증상유효，안전성호，무엄중불량반응。
[ABSTRACT]Objective: To evaluate the curative effect on Chinese medicine Xiang Shao particle treatment of women with perimenopausal syndrome and the influence of ovarian function.Methods:The randomized controlled study was conducted by 2 months, Patients were randomly divided into Xiang Shao particle groups, they taking Xiang Shao particles 1 bag at a time, three times a day, eight weeks as a course of treatment.Petients divided into Clinmen group were served 21 days, Clinmen (the first11pieces with pentanoic acid estradiol 2 mg/piece, after 10 pieces also contained cyproterone acetate 1 mg/film).Drug withdrawal and menstrual begins, then taked next course of drugs on the fifth day of menstrual, two courses of continuous administration.Recorded the symptoms (such as breast bilges) of patients during the study period, used modified Kupperman symptoms (K) score evaluating Perimenopausal symptoms during follow-up, detected serum estradiol (E2), follicle-stimulating hormone (FSH), evaluated the treatment response.Results: After treatment, K score shows Xiang Shao particle group and Clinmen group of clinical effectiveness were 76.7% and 80% respectively. hectic fever score shows effectiveness were 90%and 93.33%respectively;There was no significant difference between two groups (P>0.05).Serum FSH level of Xiang Shao particle group decreased significantly (P<0.01), E2 levels were significantly increased (P<0.01). But the change is slightly lower than Climen group (P>0.05).Both two groups had no serious adverse reactions.Conclusion: Xiang Shao particle can improve perimenopausal syndrome symptoms effectively, its security is good,and with no serious adverse reactions.
