中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2014年
12期
1457-1458,1460
,共3页
结直肠癌%代谢综合征%肿瘤生物学行为
結直腸癌%代謝綜閤徵%腫瘤生物學行為
결직장암%대사종합정%종류생물학행위
Colorectal Cancer%Metabolic Syndrome%Tumor Biological Behavior
目的：评价代谢综合征（MS）与结直肠癌（CRC）的发病率及生物学行为的关系。方法：以2011年12月至2013年12月我院收治的200例CRC患者为研究对象，同期收治的216例非肿瘤患者为对照组，比较两组间MS的发病率，并对CRC组中患者伴有MS对肿瘤生物学行为的影响进行分析。结果：CRC组的MS发病率为36%（72例），明显高于对照组（P＜0.01）。MS患者的体质指数（BMI）明显偏高，且高血压史、糖尿病史与肿瘤家族史在MS患者中更常见。Logistic回归分析显示腹型肥胖、FBS＞6.11mmol/L、吸烟史和肿瘤家族史是与CRC的发生密切相关的独立因素。CRC的临床病理特征与MS没有明显的联系。结论：CRC患者的罹患MS的几率明显升高，但MS对CRC的生物学行为没有明显影响。如进一步研究能确定CRC与MS的关系，则可考虑将MS患者纳入CRC筛查的范围。
目的：評價代謝綜閤徵（MS）與結直腸癌（CRC）的髮病率及生物學行為的關繫。方法：以2011年12月至2013年12月我院收治的200例CRC患者為研究對象，同期收治的216例非腫瘤患者為對照組，比較兩組間MS的髮病率，併對CRC組中患者伴有MS對腫瘤生物學行為的影響進行分析。結果：CRC組的MS髮病率為36%（72例），明顯高于對照組（P＜0.01）。MS患者的體質指數（BMI）明顯偏高，且高血壓史、糖尿病史與腫瘤傢族史在MS患者中更常見。Logistic迴歸分析顯示腹型肥胖、FBS＞6.11mmol/L、吸煙史和腫瘤傢族史是與CRC的髮生密切相關的獨立因素。CRC的臨床病理特徵與MS沒有明顯的聯繫。結論：CRC患者的罹患MS的幾率明顯升高，但MS對CRC的生物學行為沒有明顯影響。如進一步研究能確定CRC與MS的關繫，則可攷慮將MS患者納入CRC篩查的範圍。
목적：평개대사종합정（MS）여결직장암（CRC）적발병솔급생물학행위적관계。방법：이2011년12월지2013년12월아원수치적200례CRC환자위연구대상，동기수치적216례비종류환자위대조조，비교량조간MS적발병솔，병대CRC조중환자반유MS대종류생물학행위적영향진행분석。결과：CRC조적MS발병솔위36%（72례），명현고우대조조（P＜0.01）。MS환자적체질지수（BMI）명현편고，차고혈압사、당뇨병사여종류가족사재MS환자중경상견。Logistic회귀분석현시복형비반、FBS＞6.11mmol/L、흡연사화종류가족사시여CRC적발생밀절상관적독립인소。CRC적림상병리특정여MS몰유명현적련계。결론：CRC환자적리환MS적궤솔명현승고，단MS대CRC적생물학행위몰유명현영향。여진일보연구능학정CRC여MS적관계，칙가고필장MS환자납입CRC사사적범위。
[ABSTRACT]Objective:The present study was conducted to evaluate prevalence of metabolic syndrome(MS) and its components in patients with colorectal cancer(CRC).Methods: This survey involved 200 patients with CRC hospitalized in our clinic from Dec.2011 to Dec.2013, and 216 patients without cancer were enrolled as control group.The comparison of MS risk between the two groups and the analysis on the association of biological behaviors of CRC and MS were performed.Results: A total of 72 CRC patients (36%) met MS criteria.It was significantly higher than the control group (P<0.01).BMI in MS patients was higher than other CRC patients.Disease history including hypertension, diabetes and family history of tumor were most frequent in MS patients.Logistic regression analysis indicated that abdominal obesity, FBS>6.11 mmol/L, smoking history and tumor family history were independent factors tightly linked to CRC.Pathological characteristics of CRC were not significantly associated with MS.Conclusion:The findings of present study indicated that the prevalence of MS in CRC patients is relatively high, but not associated with the biological behaviors of CRC.If this association is confirmed in future studies, MS patients should be considered in CRC screening programs.
