CAJ | 학술논문

目的：探讨降钙素原（PCT）对重症监护室患者感染的诊断价值和临床意义。方法选择2011年9月—2012年3月某院重症监护室住院患者96例，测定其 PCT、血清超敏 C 反应蛋白（HsCRP）和白细胞（WBC）计数水平，并进行统计分析。结果与非细菌感染组相比，细菌感染组患者血清中 PCT 浓度和 HsCRP 均升高，差异有统计学意义（Z 值分别为－6．102、－3．918，均 P ＜0．05）；WBC 计数比较，差异无统计学意义（Z ＝0．212，P ＞0．05）。PCT 诊断感染的灵敏度为82．35％，特异度为67．86％，阳性预测值为86．15％，阴性预测值为61．29％；PCT、HsCRP、WBC 三者 ROC 曲线下面积分别为0．898、0．755、0．581。结论 PCT 预测细菌感染的敏感度和特异度较高，有助于早期发现危重患者的细菌感染，是诊断细菌感染价值较高的指标。
목적：탐토강개소원（PCT）대중증감호실환자감염적진단개치화림상의의。방법선택2011년9월—2012년3월모원중증감호실주원환자96례，측정기 PCT、혈청초민 C 반응단백（HsCRP）화백세포（WBC）계수수평，병진행통계분석。결과여비세균감염조상비，세균감염조환자혈청중 PCT 농도화 HsCRP 균승고，차이유통계학의의（Z 치분별위－6．102、－3．918，균 P ＜0．05）；WBC 계수비교，차이무통계학의의（Z ＝0．212，P ＞0．05）。PCT 진단감염적령민도위82．35％，특이도위67．86％，양성예측치위86．15％，음성예측치위61．29％；PCT、HsCRP、WBC 삼자 ROC 곡선하면적분별위0．898、0．755、0．581。결론 PCT 예측세균감염적민감도화특이도교고，유조우조기발현위중환자적세균감염，시진단세균감염개치교고적지표。
Objective To evaluate diagnostic value and clinical significance of procalcitonin (PCT)in infection in intensive care unit (ICU)patients.Methods 96 ICU patients in a hospital between September 2011 and March 2012 were selected for study,levels of patients’PCT,high-sensitivity C-reactive protein (HsCRP)and white blood cell (WBC)count were detected,statistical analysis were conducted.Results Compared with non-bacteria infected patients,serum PCT and HsCRP levels in all bacteria infected patients increased,the difference were significant (Z=-6.102;-3.918,both P <0.05 );WBC count was not significantly different(Z =0.212.P >0.05).PCT sensi-tivity,specificity,positive predictive value,and negative predictive value for diagnosing infection was 82.35%, 67.86%,86.15%,and 61 .29% respectively;receiver operating characteristic (ROC)curve of PCT,HsCRP,and WBC was 0.898,0.755,and 0.581 respectively.Conclusion There are higher sensitivity and specificity of PCT to predict infection,which is helpful for early detection of infection in critically ill patients.