中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
1期
164-166
,共3页
黄凤娇%庞聪%惠晓琳%李继洪
黃鳳嬌%龐聰%惠曉琳%李繼洪
황봉교%방총%혜효림%리계홍
三升金丹胶囊%一般药理%中枢神经系统%心血管系统%呼吸系统
三升金丹膠囊%一般藥理%中樞神經繫統%心血管繫統%呼吸繫統
삼승금단효낭%일반약리%중추신경계통%심혈관계통%호흡계통
Sansheng Jindan capsules%General pharmacology%Central nervous system%Cardiovascular system%Respiratory system
目的：：观察三升金丹胶囊的一般药理作用,为临床用药和安全用药提供信息。方法：采用一般行为观察实验、戊巴比妥钠阈下催眠实验、自发活动实验、转棒实验考察供试品对小鼠中枢神经系统的影响,三升金丹胶囊低中高剂量分别为90,180,360 mg·kg-1；通过检测麻醉状态下Beagle犬的血压、心电及呼吸参数来考察供试品对犬心血管系统及呼吸系统的影响,三升金丹胶囊低中高剂量分别为16,32,64 mg·kg-1。结果：小鼠给予供试品后无异常行为出现、供试品与戊巴比当钠无协同催眠作用、供试品对小鼠的自发活动及机体的协调能力没有影响(P>0.05),对麻醉状态下Beagle犬的血压、心电及呼吸也无明显影响(P>0.05)。结论：在所设计的剂量水平下,三升金丹胶囊对小鼠中枢神经系统、对犬呼吸系统和心血管系统无明显影响。
目的：：觀察三升金丹膠囊的一般藥理作用,為臨床用藥和安全用藥提供信息。方法：採用一般行為觀察實驗、戊巴比妥鈉閾下催眠實驗、自髮活動實驗、轉棒實驗攷察供試品對小鼠中樞神經繫統的影響,三升金丹膠囊低中高劑量分彆為90,180,360 mg·kg-1；通過檢測痳醉狀態下Beagle犬的血壓、心電及呼吸參數來攷察供試品對犬心血管繫統及呼吸繫統的影響,三升金丹膠囊低中高劑量分彆為16,32,64 mg·kg-1。結果：小鼠給予供試品後無異常行為齣現、供試品與戊巴比噹鈉無協同催眠作用、供試品對小鼠的自髮活動及機體的協調能力沒有影響(P>0.05),對痳醉狀態下Beagle犬的血壓、心電及呼吸也無明顯影響(P>0.05)。結論：在所設計的劑量水平下,三升金丹膠囊對小鼠中樞神經繫統、對犬呼吸繫統和心血管繫統無明顯影響。
목적：：관찰삼승금단효낭적일반약리작용,위림상용약화안전용약제공신식。방법：채용일반행위관찰실험、무파비타납역하최면실험、자발활동실험、전봉실험고찰공시품대소서중추신경계통적영향,삼승금단효낭저중고제량분별위90,180,360 mg·kg-1；통과검측마취상태하Beagle견적혈압、심전급호흡삼수래고찰공시품대견심혈관계통급호흡계통적영향,삼승금단효낭저중고제량분별위16,32,64 mg·kg-1。결과：소서급여공시품후무이상행위출현、공시품여무파비당납무협동최면작용、공시품대소서적자발활동급궤체적협조능력몰유영향(P>0.05),대마취상태하Beagle견적혈압、심전급호흡야무명현영향(P>0.05)。결론：재소설계적제량수평하,삼승금단효낭대소서중추신경계통、대견호흡계통화심혈관계통무명현영향。
90,180 and 360 mg·kg-1 on general central nervous system (CNS) of mice was investigated by general behavior observation, nembu-tal subthreshold hypnosis experiment, spontaneous activity test and rotary rod test. The changes in blood pressure, heart rate, electro-cardiogram, breathing flow and frequency in anaesthetic Bealge dogs were observed to evaluate the effects of the capsules respectively at the low, medium and high dosage of 16,32 and 64 mg·kg-1 on cardiovascular and respiratory systems. Results:The general behavior of mice was normal after the administration of Sansheng Jindan capsules. The capsules showed no synergetic hypnotic effect on nembu-tal, and had no influence on the spontaneous activity and body coordination ability of mice (P>0. 05). The blood pressure, ECG and respiratory index of anaesthetic Bealge dogs were also normal after the administration of the capsules (P>0. 05). Conclusion:There are no significant effects of Sansheng Jindan capsules at the experimental dosages on central nervous system of mice and respiratory and cardiovascular systems of Beagle dogs.
