CAJ | 학술논문

目的：：评价头孢替安钠与呋塞米合用的安全性，为临床用药提供参考。方法：设空白组、头孢替安钠500 mg · kg-1·d-1组、头孢替安钠500 mg·kg-1·d-1+呋塞米15 mg·kg-1·d-1组，给药12d后检测大鼠肾脏结构，以及血清尿酸、肌酐、尿素氮，大鼠尿α1微球蛋白，β2微球蛋白等水平。结果：头孢替安钠500 mg·kg-1·d-1给药后对大鼠的肾脏结构，血清尿酸、肌酐、尿素氮，大鼠尿α1微球蛋白、β2微球蛋白无明显影响，头孢替安钠500 mg·kg-1·d-1+呋塞米15 mg·kg-1·d-1给药后引起大鼠尿β2微球蛋白显著上升(P<0.05)，血清尿酸显著下降(P<0.05)。结论：短期使用头孢替安钠对大鼠的肾功能及肾脏结构无明显影响，而头孢替安钠+呋塞米对大鼠尿β2微球蛋白及血清尿酸有一定影响。
목적：：평개두포체안납여부새미합용적안전성，위림상용약제공삼고。방법：설공백조、두포체안납500 mg · kg-1·d-1조、두포체안납500 mg·kg-1·d-1+부새미15 mg·kg-1·d-1조，급약12d후검측대서신장결구，이급혈청뇨산、기항、뇨소담，대서뇨α1미구단백，β2미구단백등수평。결과：두포체안납500 mg·kg-1·d-1급약후대대서적신장결구，혈청뇨산、기항、뇨소담，대서뇨α1미구단백、β2미구단백무명현영향，두포체안납500 mg·kg-1·d-1+부새미15 mg·kg-1·d-1급약후인기대서뇨β2미구단백현저상승(P<0.05)，혈청뇨산현저하강(P<0.05)。결론：단기사용두포체안납대대서적신공능급신장결구무명현영향，이두포체안납+부새미대대서뇨β2미구단백급혈청뇨산유일정영향。
Objective:To evaluate the safety of the combination of cefotiam sodium and furosemide and to provide the reference for clinical medication. Methods:Three groups were established, including the blank control group, cefotiam sodium group at the dosage of 500 mg·kg-1 ·d-1 , cefotiam sodium combined with furosemide group at the respective dosage of 500 mg·kg-1 ·d-1 and 15 mg ·kg-1 ·d-1 . After the continuous administration for 12 days, the renal structure, serum uric acid, creatinine and urea nitrogen, u-rine of α1 microglobulin and β2 microglobulin in the rats were detected. Results:Cefotiam sodium at the dosage of 500 mg·kg-1 · d-1 showed no significant effects on the renal structure, serum uric acid, creatinine and urea nitrogen,urineα1 microglobulin andβ2 microglobulin in the rats. The combination group showed significantly increased urine β2 microglobulin (P<0. 05) and significantly decreased serum uric acid (P<0. 05). Conclusion:Short time use of cefotiam sodium exhibits no significant effect on the renal struc-ture and function in rats, while the combination of cefotiam sodium and furosemide has significant effects on urineβ2 microglobulin and serum uric acid in rats.