中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
1期
89-90,91
,共3页
慢性牙周炎%米诺环素软膏%超敏C反应蛋白%白介素-10
慢性牙週炎%米諾環素軟膏%超敏C反應蛋白%白介素-10
만성아주염%미낙배소연고%초민C반응단백%백개소-10
Chronic periodontitis%Minocycline-HCl ointments%High sensitivity C reaction protein ( hs-CRP )%Interleukin-10 (IL-10)
目的：：观察米诺环素软膏局部用药对慢性牙周炎患者龈沟液中超敏C反应蛋白(hs-CRP)和白介素-10(IL-10)水平的影响及其疗效。方法：慢性牙周炎患者72例(96颗牙)随机分为观察组(36例,47颗牙)和对照组(36例,49颗牙)。两组患者均常规予以龈上洁治、龈下刮治和根面平整等牙周基础治疗。观察组予米诺环素软膏注满牙周袋内；对照组予复方碘甘油液适量注入牙周袋内。1次/周,连用4周。观察两组患者治疗前后龈沟液中hs-CRP和IL-10水平的变化,比较两组临床疗效。结果：治疗4周后,两组患者龈沟液中hs-CRP水平均明显下降,IL-10水平均明显上升(P<0.01或0.05),且观察组下降或上升值较对照组更明显(P<0.05)。观察组临床总有效率为94.44%,明显优于对照组的77.78%(P<0.05)。结论：米诺环素软膏局部用药治疗慢性牙周炎的效果良好,能降低龈沟液中hs-CRP水平,升高IL-10水平,从而有效控制牙周组织的炎性破坏,改善牙周局部炎症反应状况。
目的：：觀察米諾環素軟膏跼部用藥對慢性牙週炎患者齦溝液中超敏C反應蛋白(hs-CRP)和白介素-10(IL-10)水平的影響及其療效。方法：慢性牙週炎患者72例(96顆牙)隨機分為觀察組(36例,47顆牙)和對照組(36例,49顆牙)。兩組患者均常規予以齦上潔治、齦下颳治和根麵平整等牙週基礎治療。觀察組予米諾環素軟膏註滿牙週袋內；對照組予複方碘甘油液適量註入牙週袋內。1次/週,連用4週。觀察兩組患者治療前後齦溝液中hs-CRP和IL-10水平的變化,比較兩組臨床療效。結果：治療4週後,兩組患者齦溝液中hs-CRP水平均明顯下降,IL-10水平均明顯上升(P<0.01或0.05),且觀察組下降或上升值較對照組更明顯(P<0.05)。觀察組臨床總有效率為94.44%,明顯優于對照組的77.78%(P<0.05)。結論：米諾環素軟膏跼部用藥治療慢性牙週炎的效果良好,能降低齦溝液中hs-CRP水平,升高IL-10水平,從而有效控製牙週組織的炎性破壞,改善牙週跼部炎癥反應狀況。
목적：：관찰미낙배소연고국부용약대만성아주염환자간구액중초민C반응단백(hs-CRP)화백개소-10(IL-10)수평적영향급기료효。방법：만성아주염환자72례(96과아)수궤분위관찰조(36례,47과아)화대조조(36례,49과아)。량조환자균상규여이간상길치、간하괄치화근면평정등아주기출치료。관찰조여미낙배소연고주만아주대내；대조조여복방전감유액괄량주입아주대내。1차/주,련용4주。관찰량조환자치료전후간구액중hs-CRP화IL-10수평적변화,비교량조림상료효。결과：치료4주후,량조환자간구액중hs-CRP수평균명현하강,IL-10수평균명현상승(P<0.01혹0.05),차관찰조하강혹상승치교대조조경명현(P<0.05)。관찰조림상총유효솔위94.44%,명현우우대조조적77.78%(P<0.05)。결론：미낙배소연고국부용약치료만성아주염적효과량호,능강저간구액중hs-CRP수평,승고IL-10수평,종이유효공제아주조직적염성파배,개선아주국부염증반응상황。
Objective:To observe the curative effect of local application of minocycline-HCl ointments and the influence on high sensitivity C reaction protein (hs-CRP) and interleukin-10 (IL-10) levels in gingival crevicular fluid of patients with chronic periodon-titis. Methods:Totally 72 cases of patients with chronic periodontitis (96 teeth) were selected and divided into the observation group (36 cases, 47 teeth) and the control group (36 cases, 49 teeth) by a random number table. The patients in the two groups were given the routine periodental non-surgical treatment, such as supragingival scaling, subgingival scaling, scaling and root planning etc. The patients in the observation group were given minocycline-HCl ointments filled in the periodontal pockets, and the patients in the control group were given compound iodine glycerol liquids filled in the periodontal pockets once a week for 4 weeks. The changes in hs-CRP and IL-10 levels in gingival crevicular fluid of the patients before and after the medical treatment were observed, and the clinical cura-tive effect was compared as well. Results:After the 4-week medical treatment, the hs-CRP levels in gingival crevicular fluid of the pa-tients in the two groups were obviously declined, while the IL-10 levels were obviously increased(P<0. 01 or P<0. 05), and the de-clining or increasing rate in the observation group was much higher than that in the control group (P<0. 05). The total clinical effi-ciency in the observation group was 94. 44%, which was much higher than that in the control group (77. 78%, P<0. 05). Conclu-sion:The local application of minocycline-HCl has favorable curative effect on chronic periodontitis, which can reduce the hs-CRP lev-els in gingival crevicular fluid, increase the IL-10 levels, control the inflammatory damage in periodontium effectively and improve the local inflammatory reaction in periodontium.
