中国药师
中國藥師
중국약사
CHINA PHARMACIST
2015年
1期
69-73
,共5页
郑玉忠%张振霞%谢丽玲%乐智勇%贺震旦%詹华强%曹晖
鄭玉忠%張振霞%謝麗玲%樂智勇%賀震旦%詹華彊%曹暉
정옥충%장진하%사려령%악지용%하진단%첨화강%조휘
山药%总灰分%硫熏%浸润%无机盐
山藥%總灰分%硫熏%浸潤%無機鹽
산약%총회분%류훈%침윤%무궤염
Dioscoreae Rhizoma%Total ash%Sulfur-fumigation%Water-soaking%Mineral salt
目的：：探索硫熏或清水浸润对山药总灰分的影响及其机制，揭示影响山药总灰分的关键因素，探讨《中国药典》中山药灰分限量的合理性。方法：分别采用硫磺熏蒸和清水浸润的方法对山药进行处理，依据《中国药典》收载的灰分和SO2测定方法测定山药总灰分含量变化，根据无机盐灰分变化来探讨其作用机制。结果：硫熏会轻微减低山药的总灰分含量；而硫熏会显著减低草酸钙和硫酸钙的总灰分含量，降幅分别为7.20%和9.90%，但对磷酸钙和氯化钙的影响很小；说明硫熏对灰分的影响主要是通过提高草酸钙和硫酸钙等分解率来实现的。清水浸润能使山药总灰分含量下降，这种现象普遍存在于根茎类药材中，它对总灰分的影响要大于硫熏。结论：硫熏是通过提高草酸钙和硫酸钙等分解率来降低山药中的总灰分含量，但是影响有限，因此硫熏不是影响山药总灰分的主要因素。山药饮片制作过程中浸润会使山药中的水溶性无机盐类( Cl-、C2 O42-、NO3-和SO42-等离子)大量流失，导致总灰分量降低，因此浸润是影响山药总灰分的关键因素。
目的：：探索硫熏或清水浸潤對山藥總灰分的影響及其機製，揭示影響山藥總灰分的關鍵因素，探討《中國藥典》中山藥灰分限量的閤理性。方法：分彆採用硫磺熏蒸和清水浸潤的方法對山藥進行處理，依據《中國藥典》收載的灰分和SO2測定方法測定山藥總灰分含量變化，根據無機鹽灰分變化來探討其作用機製。結果：硫熏會輕微減低山藥的總灰分含量；而硫熏會顯著減低草痠鈣和硫痠鈣的總灰分含量，降幅分彆為7.20%和9.90%，但對燐痠鈣和氯化鈣的影響很小；說明硫熏對灰分的影響主要是通過提高草痠鈣和硫痠鈣等分解率來實現的。清水浸潤能使山藥總灰分含量下降，這種現象普遍存在于根莖類藥材中，它對總灰分的影響要大于硫熏。結論：硫熏是通過提高草痠鈣和硫痠鈣等分解率來降低山藥中的總灰分含量，但是影響有限，因此硫熏不是影響山藥總灰分的主要因素。山藥飲片製作過程中浸潤會使山藥中的水溶性無機鹽類( Cl-、C2 O42-、NO3-和SO42-等離子)大量流失，導緻總灰分量降低，因此浸潤是影響山藥總灰分的關鍵因素。
목적：：탐색류훈혹청수침윤대산약총회분적영향급기궤제，게시영향산약총회분적관건인소，탐토《중국약전》중산약회분한량적합이성。방법：분별채용류광훈증화청수침윤적방법대산약진행처리，의거《중국약전》수재적회분화SO2측정방법측정산약총회분함량변화，근거무궤염회분변화래탐토기작용궤제。결과：류훈회경미감저산약적총회분함량；이류훈회현저감저초산개화류산개적총회분함량，강폭분별위7.20%화9.90%，단대린산개화록화개적영향흔소；설명류훈대회분적영향주요시통과제고초산개화류산개등분해솔래실현적。청수침윤능사산약총회분함량하강，저충현상보편존재우근경류약재중，타대총회분적영향요대우류훈。결론：류훈시통과제고초산개화류산개등분해솔래강저산약중적총회분함량，단시영향유한，인차류훈불시영향산약총회분적주요인소。산약음편제작과정중침윤회사산약중적수용성무궤염류( Cl-、C2 O42-、NO3-화SO42-등리자)대량류실，도치총회분량강저，인차침윤시영향산약총회분적관건인소。
Objective:To study the effect and underlying mechanism of sulfur-fumigation and water-soaking on total ash of Di-oscoreae Rhizoma, find the key factor( s) affecting the total ash of Dioscoreae Rhizoma, and explore the rationality of ash limits of Di-oscoreae Rhizoma described in Chinese Pharmacopoeia. Methods:Dioscoreae Rhizoma was respectively dealt with sulfur-fumigation and water-soaking. The changes in total ash content of Dioscoreae Rhizoma was detected by the ash determination methods for total ash and SO2 described in the pharmacopoeia, and then the ash content change of inorganic salts was used to study the mechanism. Results:Sulfur-fumigation could slightly reduce the total ash content of Dioscoreae Rhizoma, while significantly reduce the ash content of calcium oxalate and calcium sulfate with the reduction degree of 7. 20% and 9. 90%, respectively. Calcium phosphate and calcium chloride were slightly affected by sulfur-fumigation, and the results indicated that the effect of sulfur-fumigation on ash content was mainly real-ized by increasing the decomposition rate of calcium oxalate and calcium sulfate. Water-soaking could decline the ash content of Di-oscoreae Rhizoma, and the phenomenon was common in the rhizome medicinal materials. The influence of water-soaking on total ash was more significant than that of sulfur fumigation. Conclusion:Sulfur-fumigation can reduce the total ash content of Dioscoreae Rhizo-ma by increasing the decomposition rate of calcium oxalate and calcium sulfate, however, the effect is mild and the process isn't the key influencing factor in the total ash content of Dioscoreae Rhizoma. During the preparation of Dioscoreae Rhizoma medicinal slices, water-soaking can cause the great loss of water-soluble mineral salts, such as Cl-, C2 O4 2-, NO3 - and SO4 2-, which leads to the reduction of total ash content, therefore, water-soaking is the key influencing factor in the total ash content of Dioscoreae Rhizoma.
