CAJ | 학술논문

目的：：测定消积癌痛巴布剂中延胡索乙素释放度及离体大鼠透皮率测定研究。方法：以自制的释放度装置以及改良的Franz扩散池,以离体的大鼠皮肤为屏障,以HPLC测定消积癌痛巴布剂中不同时间延胡索乙素的释放度及透皮累计量。结果：延胡索乙素在0.51~10.22μg范围内线性关系良好(r=0.9997),平均回收率为98.49%(RSD=0.84%,n=9),通过HPLC测得消积癌痛巴布剂中的延胡索乙素80 min的释放度为63.60%,透过离体大鼠皮肤24 h的透皮率为23.15%。结论：消积癌痛巴布剂具有良好的释放度及透皮性能。
목적：：측정소적암통파포제중연호색을소석방도급리체대서투피솔측정연구。방법：이자제적석방도장치이급개량적Franz확산지,이리체적대서피부위병장,이HPLC측정소적암통파포제중불동시간연호색을소적석방도급투피루계량。결과：연호색을소재0.51~10.22μg범위내선성관계량호(r=0.9997),평균회수솔위98.49%(RSD=0.84%,n=9),통과HPLC측득소적암통파포제중적연호색을소80 min적석방도위63.60%,투과리체대서피부24 h적투피솔위23.15%。결론：소적암통파포제구유량호적석방도급투피성능。
Objective:To determine the release and in vitro transdermal rate of tetrahydropalmatine in Xiaoji Aitong cataplasmas in rats. Methods:Using the self-made drug release determination devices and the modified Franz diffusion cells, and the skin of rats as the barrier, the release and in vitro transdermal rate of tetrahydropalmatine in Xiaoji Aitong cataplasmas were detected by HPLC. Re-sults:Tetraydropalmatine within the range of 0. 51-10. 22 μg showed a good linearity (r=0. 999 7), and the average recovery was 98. 49%(RSD=0. 84%,n =9). The release of tetrahydropalmatine in 80 min was 63. 60%, and the skin permeation rate was 23. 15% in 24h. Conclusion:Xiaoji Aitong cataplasmas have good drug release and transdermal performance.