CAJ | 학술논문

目的：探讨ST段抬高型急性心肌梗死行强化他汀治疗的疗效及安全性。方法：2013年4月-2014年4月收治ST段抬高型急性心肌梗死患者106例，随机分为研究组和对照组各53例，均行常规治疗，研究组加服阿托伐他汀40 mg/d，对照组加服阿托伐他汀20 mg/d，比较两组疗效和心血管事件发生情况。结果：研究组的 Hs-CRP、TC和LDC-C下降幅度是明显大于对照组(P＜0.05)，两组的CK、HDL-C和TG变化差异无统计学意义(P＞0.05)；研究组的心血管事件发生率3.77%明显低于对照组的20.75%(P＜0.05)。结论：ST段抬高型急性心肌梗死行强化他汀治疗的疗效较为显著。
목적：탐토ST단태고형급성심기경사행강화타정치료적료효급안전성。방법：2013년4월-2014년4월수치ST단태고형급성심기경사환자106례，수궤분위연구조화대조조각53례，균행상규치료，연구조가복아탁벌타정40 mg/d，대조조가복아탁벌타정20 mg/d，비교량조료효화심혈관사건발생정황。결과：연구조적 Hs-CRP、TC화LDC-C하강폭도시명현대우대조조(P＜0.05)，량조적CK、HDL-C화TG변화차이무통계학의의(P＞0.05)；연구조적심혈관사건발생솔3.77%명현저우대조조적20.75%(P＜0.05)。결론：ST단태고형급성심기경사행강화타정치료적료효교위현저。
Objective:To explore the efficacy and safety of strengthening statin therapy in ST segment elevation acute myocardial infarction.Methods:106 patients with ST segment elevation acute myocardial infarction were selected from April 2013 to April 2014.They were randomly divided into the study group and the control group with 53 cases in each group.Two groups were given routine therapy.The study group added atorvastatin 40 mg/day.The control group added atorvastatin 20 mg/day.We compared the efficacy and the incidence of cardiovascular event of the two groups.Results:In the study group,the decline rate of Hs-CRP,TC and LDC-C was obviously higher than that of the control group(P<0.05),and there was no significant difference of CK,HDL-C and TG changes of the two groups(P>0.05);in the study group,the incidence rate of cardiovascular events was 3.77%,which was significantly lower than the control group with 20.75%(P<0.05).Conclusion:The efficacy of strengthening statin therapy in ST segment elevation acute myocardial infarction is significant.