中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2015年
1期
5-6
,共2页
卓子禄%王群英%熊英%胡俊英
卓子祿%王群英%熊英%鬍俊英
탁자록%왕군영%웅영%호준영
阿立哌唑口腔崩解片%利培酮%舒必利%奥氮平
阿立哌唑口腔崩解片%利培酮%舒必利%奧氮平
아립고서구강붕해편%리배동%서필리%오담평
Aripiprazole orally disintegrating tablets%Risperidone,Sulpiride,Olanzapine
目的:探讨阿立哌唑口腔崩解片改善利培酮、舒必利、奥氮平等精神类药物所致体重、泌乳素增加的临床效果。方法:收治因服用利培酮、舒必利、奥氮平等精神类药物后引起体重增加及高催乳素血症患者60例,所有患者均维持原抗精神类药物的治疗方案,根据随机数字表将患者分为阿立哌唑口腔崩解片组(观察组)30例和安慰剂组(对照组)30例,两组患者干预12周后测量患者体质指数(BMI)变化及催乳素(PRI)的水平,同时采用不良反应量表(TESS)评定阿立哌唑口腔崩解片治疗的不良反应。结果:与对照组相比,观察组治疗后 BMI 及PRL 显著下降,差异有统计学意义(P<0.01)。观察组总有效率93.33%,对照组总有效率76.67%,两组比较有统计学意义(P<0.05)。TESS 评分观察组(5.12±1.12)分,对照组(4.98±1.08)分,两组比较差异无统计学意义(P>0.05)。结论:阿立哌唑口腔崩解片能有效改善利培酮、舒必利、奥氮平等抗精神病药所致体重、泌乳素增加症状,且安全、可靠,值得临床应用和推广。
目的:探討阿立哌唑口腔崩解片改善利培酮、舒必利、奧氮平等精神類藥物所緻體重、泌乳素增加的臨床效果。方法:收治因服用利培酮、舒必利、奧氮平等精神類藥物後引起體重增加及高催乳素血癥患者60例,所有患者均維持原抗精神類藥物的治療方案,根據隨機數字錶將患者分為阿立哌唑口腔崩解片組(觀察組)30例和安慰劑組(對照組)30例,兩組患者榦預12週後測量患者體質指數(BMI)變化及催乳素(PRI)的水平,同時採用不良反應量錶(TESS)評定阿立哌唑口腔崩解片治療的不良反應。結果:與對照組相比,觀察組治療後 BMI 及PRL 顯著下降,差異有統計學意義(P<0.01)。觀察組總有效率93.33%,對照組總有效率76.67%,兩組比較有統計學意義(P<0.05)。TESS 評分觀察組(5.12±1.12)分,對照組(4.98±1.08)分,兩組比較差異無統計學意義(P>0.05)。結論:阿立哌唑口腔崩解片能有效改善利培酮、舒必利、奧氮平等抗精神病藥所緻體重、泌乳素增加癥狀,且安全、可靠,值得臨床應用和推廣。
목적:탐토아립고서구강붕해편개선리배동、서필리、오담평등정신류약물소치체중、비유소증가적림상효과。방법:수치인복용리배동、서필리、오담평등정신류약물후인기체중증가급고최유소혈증환자60례,소유환자균유지원항정신류약물적치료방안,근거수궤수자표장환자분위아립고서구강붕해편조(관찰조)30례화안위제조(대조조)30례,량조환자간예12주후측량환자체질지수(BMI)변화급최유소(PRI)적수평,동시채용불량반응량표(TESS)평정아립고서구강붕해편치료적불량반응。결과:여대조조상비,관찰조치료후 BMI 급PRL 현저하강,차이유통계학의의(P<0.01)。관찰조총유효솔93.33%,대조조총유효솔76.67%,량조비교유통계학의의(P<0.05)。TESS 평분관찰조(5.12±1.12)분,대조조(4.98±1.08)분,량조비교차이무통계학의의(P>0.05)。결론:아립고서구강붕해편능유효개선리배동、서필리、오담평등항정신병약소치체중、비유소증가증상,차안전、가고,치득림상응용화추엄。
Objective:To explore the clinical effect of aripiprazole orally disintegrating tablets in the improvement of women's weight,prolactin increase caused by sulpiride,risperidone,olanzapine.Methods:60 cases of weight gain and hyperprolactinemic patients caused by sulpiride,risperidone,olanzapine were selected.All patients maintained antipsychotic drug treatment scheme of the original.According to the random number table,they were divided into the aripiprazole orally disintegrating tablets group(observation group) with 30 cases and the placebo group(control group) with 30 cases.After 12 weeks of treatment,we measured body mass index patients(BMI) changes and prolactin(PRI) level.At the same time,we evaluated the adverse reactions of aripiprazole orally disintegrating tablets treatment using side effects scale(TESS).Results:Compared with the control group,after treatment,BMI and PRL of the observation group was decreased significantly,and the difference was statistically significant(P<0.01).In the observation group,the total efficiency was 93.33%;in the control group,the total efficiency was 76.67%;the difference was statistically significant(P<0.05).In the observation group,the TESS score was (5.12+1.12);the control group was (4.98+1.08);there was no significant difference(P>0.05).Conclusion:Aripiprazole orally disintegrating tablets can effectively improve the women's weight,prolactin increase caused by sulpiride,risperidone,olanzapine,and it is safe and reliable.It is worthy of clinical application and promotion.